Addiction Etter 2013.pdf


Aperçu du fichier PDF addiction-etter-2013.pdf - page 6/9

Page 1 2 3 4 5 6 7 8 9


Aperçu texte


6

Jean-François Etter et al.

Table 2 Amount of nicotine in the samples.

Sample no.

Brand and model

1

Forever Vapor USA Mix

2

Forever Vapor Menthol

3

Ecigexpress Premium Tobacco

4

Ecigexpress USA Mix

5

Ecigexpress Minty Menthol

6

Ecigexpress Unflavored PG base

7

Janty Orange

8

Janty Flavorless

9

Janty TXS-H

10

Totally Wicked Pillbox 38—High 18 mg

11

Totally Wicked Pillbox 38—Patriot Range

12

Vapor4life V4L-555 Nobacco Juice

13

Vapor4life V4L-Nobacco Juice Gunslinger

14

Sedansa Turkish Blend

15

Sedansa Anatolia

16

Johnson Creek JC Original

17

Johnson Creek Tennessee Cured

18

Tecc Titan Fluid, Flavor M/Borough

19

Intellicig Rich X-high

20

Dekang Western Conqueror

Nicotine
(mg/mL)

Labeled nicotine
content

% of label

20.3
25.3
24.6
26.8
21.8
18.0
25.7
23.7
17.8
17.8
6.0
6.0
15.2
15.0
23.5
22.2
16.1
15.9
17.7
18.4
16.1
16.7
22.3
23.6
22.9
25.1
nd
nd
nd
nd
25.7
25.4
24.5
25.0
17.5
17.2
29.0
28.4
11.7
12.5

24 mg
24 mg
24 mg
24 mg
18 mg/mL
18 mg/mL
24 mg
24 mg
18 mg/mL
18 mg/mL
6 mg
6 mg
16 mg
16 mg
24 mg
24 mg
16 mg
16 mg
18 mg
18 mg
18 mg
18 mg
24 mg
24 mg
24 mg
24 mg
ns
ns
ns
ns
24 mg
24 mg
24 mg
24 mg
18 mg
18 mg
30 mg
30 mg
12 mg
12 mg

85
106
102
112
121
100
107
99
99
99
101
100
95
94
98
93
101
99
98
102
90
93
93
98
95
105
na
na
na
na
107
106
102
104
97
96
97
95
98
104

nd = not detected; ns = nicotine content not specified on label; na = not applicable. Results for two replicates are presented for each sample.

practice, and all excipients must show proof of good
quality and well-established characteristics. The container must be tested and made of inert material. Most
e-liquids probably do not fulfill these requirements, but
e-liquids are currently marketed as alternatives to
tobacco, rather than medications. Our analysis did not
investigate how the solutions, or the nicotine or other
excipients, were produced, how the solutions might be
affected when added to the e-cigarette, long-term stability, in-use stability, or how the solutions are affected when
heated, vaporized and inhaled.
© 2013 Society for the Study of Addiction

The nicotine content in the samples generally corresponded to the labels on the bottles, and differences
between content and labels were smaller than previously
reported [20,24], which suggests that the manufacturing
processes has improved over time. The bottles of e-liquid
are dangerous as they contain up to 720 mg of nicotine,
which is several times the fatal dose of nicotine (and
larger bottles are available online). The acute minimum
lethal oral dose of nicotine is 40–60 mg in children (oral
intake of tobacco from cigarettes) or 0.8–1.0 mg/kg of
body weight in adult non-smokers [38].
Addiction