chocolat .pdf


Nom original: chocolat.pdfAuteur: BERNARD

Ce document au format PDF 1.5 a été généré par Conv2pdf.com, et a été envoyé sur fichier-pdf.fr le 11/11/2014 à 19:43, depuis l'adresse IP 212.195.x.x. La présente page de téléchargement du fichier a été vue 830 fois.
Taille du document: 233 Ko (2 pages).
Confidentialité: fichier public


Aperçu du document


Enhancing dentate gyrus function with dietary
flavanols improves cognition in older adults













Adam M Brickman,
Usman A Khan,
Frank A Provenzano,
Lok-Kin Yeung,
Wendy Suzuki,
Hagen Schroeter,
Melanie Wall,
Richard P Sloan
& Scott A Small
Affiliations
Contributions
Corresponding author
Nature Neuroscience
(2014)
doi:10.1038/nn.3850
Received
26 June 2014
Accepted
01 October 2014
Published online
26 October 2014
Corrected online
02 November 2014
Article tools












Citation
Reprints
Rights & permissions
Article metrics

Abstract
Abstract•
Change history•
References•
Author information•
Supplementary information

The dentate gyrus (DG) is a region in the hippocampal formation whose function declines in
association with human aging and is therefore considered to be a possible source of agerelated memory decline. Causal evidence is needed, however, to show that DG-associated
memory decline in otherwise healthy elders can be improved by interventions that enhance
DG function. We addressed this issue by first using a high-resolution variant of functional

magnetic resonance imaging (fMRI) to map the precise site of age-related DG dysfunction
and to develop a cognitive task whose function localized to this anatomical site. Then, in a
controlled randomized trial, we applied these tools to study healthy 50–69-year-old subjects
who consumed either a high or low cocoa flavanol–containing diet for 3 months. A highflavanol intervention was found to enhance DG function, as measured by fMRI and by
cognitive testing. Our findings establish that DG dysfunction is a driver of age-related
cognitive decline and suggest non-pharmacological means for its amelioration.


Aperçu du document chocolat.pdf - page 1/2

Aperçu du document chocolat.pdf - page 2/2




Télécharger le fichier (PDF)


chocolat.pdf (PDF, 233 Ko)

Télécharger
Formats alternatifs: ZIP Texte



Documents similaires


chocolat
accepted manuscript feb 2013
fichier pdf sans nom 2
les pertes de memoire
bakroon et al 2016 clinical and experimental optometry
perte odorat et mortalite

Sur le même sujet..




🚀  Page générée en 0.009s