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AGE METHYLATION.pdf


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Article

Age-Associated Methylation Suppresses SPRY1,
Leading to a Failure of Re-quiescence and Loss of
the Reserve Stem Cell Pool in Elderly Muscle
Graphical Abstract

Authors
Anne Bigot, William J. Duddy, Zamalou G.
Ouandaogo, ..., Gillian Butler-Browne,
Vincent Mouly, Ste´phanie Duguez

Correspondence
vincent.mouly@upmc.fr (V.M.),
stephanie.duguez@upmc.fr (S.D.)

In Brief
Loss of muscle strength in old age is
linked to diminution of the muscle stem
cell pool. Bigot et al. show that the ageassociated increase in global DNA
methylation acts through the SPRY1
pathway to suppress human muscle stem
cell entry into quiescence, thus impairing
self-renewal of the stem cell pool.

Highlights
d

The capacity of human muscle stem cells to enter quiescence
diminishes with age

d

This reduced capacity to re-quiesce is associated with
increased DNA methylation

d

DNA methylation suppresses SPRY1, a known regulator of
quiescence

d

Senescence, a feature of late cell division counts, is not
increased with age

Bigot et al., 2015, Cell Reports 13, 1172–1182
November 10, 2015 ª2015 The Authors
http://dx.doi.org/10.1016/j.celrep.2015.09.067

Accession Numbers
GSE52699
GSE53302