PhD position Le Clainche I2BC .pdf

Nom original: PhD position Le_Clainche_I2BC.pdfAuteur: christophe

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PhD position in Biochemistry at I2BC (Paris area, France):
Study of mechanosensitive protein complexes associated to the actomyosin cytoskeleton
The Institute for Integrative Biology of the Cell (I2BC) is a new vibrant environment for research in all disciplines of
life sciences located in the south Paris area (Gif-sur-Yvette).
The PhD candidate will study the force-dependent binding of proteins
to their ligands. More specifically, he/she will study the effect of actomyosin
force on the interaction between actin-binding proteins (talin, filamin) and
integrins that mediate adhesion in many cell functions (migration,
phagocytosis…). To this aim, he/she will adapt the microscopy assay that we
developed to reconstitute the actomyosin-dependent talin-vinculin
mechanosensitive complex with pure proteins on geometrically-defined
micropatterned surfaces (Ciobanasu et al, 2014 Nature Communications;
Ciobanasu et al, 2015 Nature Protocols).

Basic principle of the assay to
study the actomyosin-dependent
talin-vinculin complex

The project is funded by ANR for 3 years (National Agency for Research) and involves a collaboration with the
group of Florence Niedergang at Cochin Institute in Paris to study the role of mechanosensitive protein complexes in
phagocytosis using cell biology approaches.
More information on I2BC, our team and our research can be found at : and
The candidate holds a Master of Science degree in Life Sciences (or interface Physics / Biology or Chemistry /
Biology). Candidates with an interdiscplinary profile are very welcome. Experience in microscopy is a plus.
Experience in protein purification is a plus.
Terms of Appointment: This position is funded for 3 years, starting in january 2017 or later. The position will remain
open until it is filled. The salary will follow the CNRS guidelines. The candidate will obtain a PhD in Biochemistry from
the University Paris-Sud under the supervision of Dr Christophe Le Clainche at I2BC.
To apply, please submit a cover letter, a detailed CV and contact information for two references by e-mail to :

Dr Christophe Le Clainche
Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, FRANCE
e-mail :

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