French Tech Berlin ESCP Trend report 1 Final1402 .pdf

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Trend  Report  |  Big  Data  &  Health  
How  Big  Data  and  Digitaliza/on  disrupt  the  Healthcare  industry  
Q1  2017  

Trend  Report  |  Big  Data  &  Health  


of  Health  

In   the   last   decade,   health   and   big   data   have  
become   more   and   more   intertwined,   to   the  
point  that  we  can  now  speak  of  the  field  of  
“Meditech”.   A   wide   designa/on,   Meditech,  
or   the   digitaliza/on   of   health,   ranges   from  
the   compila/on   of   medical   records   to   the  
use   of   connected   wearable   devices,  
designed   to   monitor   our   health   at   every  
Its   impact   on   our   life   is   real,   as   the   more  
data  we,  users,  generate,  the  more  precise  
the  analyses  are  and  the  more  solu/ons  can  
be   found.   Furthermore,   investors   are  
geMng   increasingly   interested   in   that   field,  
which   they   consider   as   one   of   the   fastest  
Luckily  for  us,  Berlin  is  a  thriving  place  when  
it  comes  to  the  digitaliza/on  of  health:  It  is  
home   to   many   hospitals,   research   centers  
or   incubators   currently   working   on   the  
health   solu/ons   of   tomorrow.   New   projects  
emerge   constantly,   each   more   innova/ve  
than  the  one  before.    
This   report   will   first   introduce   you   to   the  
latest   trends   in   big   data   and   their  
applica/on,   as   well   as   the   datafica/on   of  
health;   you   will   then   embark   on   a   journey  
through   the   Berlin   digital   health   ecosystem,  
where   you   will   meet   the   main   players   in  
that  field,  as  well  as  the  rising  actors.    
Finally,   stay   tuned   for   the   presenta/on   of  
our   favorite   project:   Teddy   the   Guardian.  
Teddy   is   a   smart   Teddy   bear,   designed   to  
collect   vital   data   on   children,   in   the  
smoothest  and  less  trauma/c  way  possible.    
We’ll   introduce   you   to   this   companion,  
which   opens   the   door   to   a   possible  
revolu/on  in  the  field  of  pediatrics.    
Get  on  board  and  follow  us  as  we  navigate  
through  this  exci/ng  field!  

Trend  Report  |  Big  Data  &  Health  

Big  Data  Trends  
Big  data  is  the  new  big  name  in  town  and  is  indeed  revolu/onizing  our  world  in  a  flash:  over  
90  percent  of  the  data  in  the  world  was  created  in  the  past  2  years.  This  is  due  to:  
•  our   extensive   online   ac6vity.   Every   minute,   we   send   204   million   emails,   generate   1.8  
million  Facebook  likes,  send  278  000  tweets,  upload  200  000  photos  on  Facebook,  etc.  
•  the   development   of   the   Internet   of   Things   (IoT),   a   system   of   interrelated   compu/ng  
devices,   mechanical   and   digital   machines,   objects,   animals   or   people   that   are   provided  
with   unique   iden/fiers   and   the   ability   to   transfer   data   over   a   network   without   requiring  
human-­‐to-­‐computer  interac/on.  
•  the   increasing   number   of   sensors   everywhere,   devices   which   detect   and   respond   to   some  
type   of   input   from   the   physical   environment   (light,   heat,   mo/on,   moisture,   pressure).   The  
output   is   generally   a   signal   that   is   converted   to   human-­‐readable   display   at   the   sensor  
loca/on  or  transmibed  electronically  over  a  network  for  reading  or  further  processing.    

We  all  produce  data,  and  data  affects  us  all.  It  is  reshaping  everything  
we   do:   from   scien/fic   research   to   business   strategy,   from   poli/cs   to  
social  interac/on.  It  is  at  the  heart  of  all  concerns  but  also  holds  the  
key  for  a  brighter  future.  
Data   today   is   not   only   defined   by   its   enormous   volume;   it   is   also  
defined  by  its  velocity  (or  speed),  its  variety  (or  different  sources),  its  
veracity   (or   completeness   and   accuracy)   and   its   value:   how   can   we  
get  the  most  out  of  all  this  data?      
This   explosion   of   unstructured   data   has   led   to   new   techniques   for  
access,   storage   and   analysis   which   are   not   within   everyone’s   reach…  
and  that  is  the  crux  of  the  maber!  Who  generates  big  data,  who  can  
store  it,  and  most  importantly,  who  can  analyze  it  to  use  it?    
While   individuals   create   70   percent   of   all   data,   enterprises   store   80  
percent   and   only   4   percent   of   companies   can   draw   meaningful  
insights  from  data  and  act  upon  it  (according  to  Bain,  2014).  Indeed,  
to  get  value  out  of  data,  you  first  need    the  right  data,  the  right  tools  -­‐  
for   instance,   Hadoop,   founded   in   2006,   was   the   first   open   source  
plagorm   des/ned   to   store   and   analyze   the   explosion   of   web   data;  
today,   HPCC   and   NoSQL   are   other   crucial   sokware   actors   -­‐   and   the  
right  people  to  deal  with  the  big  analy/cs.    


The  term  “Big  Data”  oken  triggers  nega/ve  apprecia/on:  breach  of  privacy,  commodifica/on,  
surveillance,  loss  of  control,  etc.  But  big  data,  as  such,  is  not  a  problem;  the  problem  lies  in  
how  the  data  is  used,  and  by  whom.  People  are  oken  less  aware  of  the  posi/ve  impact  big  
data   can   have   on   our   lives:   it   provides   great   tools   to   forecast,   frame   or   respond   to   large   scale  
challenges  affec/ng  the  lives  of  millions.  

Understanding  demographic  and  migratory  processes  
Tracking   cell   phones   ac/vity   via   GPS   can   help   us   understand   paberns  
of  migra/on  and  forma/on  of  social  groups  in  ci/es.  Thanks  to  "data  
mining",   the   SAS   Ins/tute,   an   American   mul/na/onal   developer   of  
analy/cs   sokware,   was   able   to   iden/fy   trends   in   unemployment   in  
the   United   States   and   Ireland   three   months   before   the   official  
reports,  by  analyzing  conversa/ons  held  on  social  media.  

Improving  our  natural  disaster  alert  systems  
The  US  Geological  Survey  watches  on  Twiber  the  increase  in  volume  
of  messages  on  earthquakes  and  temblors,  and  has  thus  been  able  to  
locate   earthquakes   with   90   percent   accuracy.   The   data   is   available  
through  their  Live  Earthquake  Map.  In  other  cases,  the  use  of  oceanic  
robo/c   sensor   systems   helps   monitor   ac/vi/es,   and   provides   real-­‐
/me  analysis  to  an/cipate  the  risk  of  tsunamis.  

Understanding  economic  trends  
MIT  researchers  have  developed  a  plagorm,  the  Billion  Prices  project,  
that   collects   data   on   the   prices   of   goods   sold   or   adver/sed   on   the  
web   on   a   daily   basis,   and   uses   it   to   es/mate   infla/on   with   high  
precision.   It   allows   them   to   iden/fy   peaks   of   infla/on   much   faster  
than  with  tradi/onal  methods.  
Detec6ng  pandemic  risks  in  real  6me  
Google   Flu   Trends   and   Google   Dengue   Trends   monitor   internet  
researches  on  the  symptoms  of  influenza  and  malaria  carried  out  in  
certain   places.   As   a   result,   they   can   detect   the   possibility   of   an  
outbreak   and   its   loca/on   at   any   /me.   Both   programs   have   now   been  
shut  down  due  to  a  couple  of  missed  predic/ons,  but  s/ll  showed  the  
way   for   future   ground-­‐breaking   and   very   precious   tools   to   monitor  
the  spread  of  diseases.      
Discovering   topographical   changes,   and   paAerns   of   traffic   and   gas  
In   the   soon-­‐to-­‐be   smart   ci/es,   electronical   and   digital   sensors  
capable   of   transferring   real   /me   data   on   the   city’s   ac/vity   will   be  
implemented.   These   sensors   can,   for   example,   change   the   dura/on  
of  the  lights  at  traffic  lights  to  ease  up  traffic  density.  


Trend  Report  |  Big  Data  &  Health  

Digitaliza/on  of  Healthcare  
Understanding  climate  change  
The   organiza/on   “Life   Under   Your   Feet”   has   created   a   tool   which  
shows  the  varia/on  in  humidity,  temperature  and  soil  pressure,  using  
data  collected  from  satellites  and  electronic  sensors.  This  informa/on  
can   be   really   useful   when   making   decisions   in   agriculture   or  
infrastructure  projects.  
Improving  public  services  
Ubidots  is  a  Colombian  IoT  plagorm  which  watches  and  monitors  the  
hygiene   condi/ons   of   25   hospitals   in   La/n   America.   The   sensors  
monitored   by   Ubidots   collect   data   on   the   hospitals’   ac/vi/es   and  
occupancy   rates,   to   get   a   real   /me   evalua/on   of   their   current  
situa/on  and  beber  manage  A&E  services.  
Improving   and   coordina6ng   humanitarian   aid   in   6mes   of   disaster  
CrisisMappers  uses  geospa/al  technologies,  mobile  communica/ons  
and   other   communica/on   plagorms   to   improve   the   distribu/on   of  
humanitarian   aid   and   coordinate   disaster   response.   Ushahidi,   a  
Kenyan-­‐based   online   plagorm   that   uses   crowdsourcing   for   social  
ac/vism  and  poli/cal  accountability  was  used  during  the  earthquake  
in  Hai/  in  2010  to  report  people  who  were  s/ll  trapped  in  buildings  
or  in  urgent  need  of  help.  
Improving  the  quality  of  life  and  strengthen  local  6es  
CoCoRaHS  is  a  network  of  volunteers  that  measures  rainfall  levels  in  
a  given  place.  With  the  collected  informa/on,  local  communi/es  can  
control   invasions   of   mosquitoes,   improve   urban   planning,   properly  
adjust   their   risk   insurance   and   even   plan   outdoor   recrea/onal   and  
educa/onal  ac/vi/es.  
Iden6fying  habits  and  social  problems  
Research   shows   that   we   some/mes   share   our   health   problems   or  
illnesses   on   social   media   more   than   we   do   with   doctors.   The   analysis  
of   informa/on   on   social   media   can   help   us   discover   poten/al  
endemic   diseases   and   beber   understand   our   health   habits,   such   as  
exercising,  or  our  consump/on  of  drugs  or  alcohol.  


Healthcare,   our   second   topic,   is   also   quickly   evolving,   becoming   more   sophis/cated,  
personalized  and  democra/zed  thanks  to  technological  advancements  and  the  explosion  of  
data.  This  sec/on  will  focus  on  technological  innova/ons.  Many  new  actors  are  disrup/ng  a  
market  previously  dominated  by  big  pharmaceu/cal  and  medical  companies.    
In   parallel,   consumer   awareness   of   their   own  
health  is  on  the  rise  for  several  reasons:    
•  Healthy   is   the   new   trendy:   an   increasing  
number   of   people   are   adop/ng   digital  
health  apps  to  manage  their  care  when  and  
where   they   want   it.   Pa/ent   adop/on   of  
health-­‐related   apps   nearly   doubled   over  
the   last   two   years.   About   32   percent   of  
consumers   had   at   least   one   health   app   on  
their   phones   in   2015,   up   from   only   16  
percent  in  2013  (PwC  report).    
•  Pa/ents  are  demonstra/ng  a  lack  of  trust  in  
tradi/onal   health   systems:   they   are   asking  
for   more   sophis/cated,   transparent,  
convenient,   affordable   and   personalized  
health  services.    
•  Devices  are  becoming  more  and  more  user-­‐
friendly:   technology   empowers   pa/ents  
thanks   to   cheap   smartphone   applica/ons,  
easy-­‐to-­‐use  connected  medical  devices  and  
intui/ve   wearables.   All   these   instruments  
are   making   healthcare   more   personalized,  
accessible,   faster,   cheaper,   par/cipatory  
and  predic/ve.    
Wearables   go   well   beyond   fitness   trackers.  
Electrocardiogram   monitors,   glucose   trackers,  
connected  pacemakers,  etc.  are  also  booming  
in   popularity:   around   110   million   will   be  
manufactured   globally   within   the   next   four  
years   (Canadian   Consumer   Wearables  
2014-­‐2018  Forecast).  These  connected  devices  
will   spur   greater   adop/on   of   apps   enabling  
pa/ents   to   monitor   their   health   and   share  
informa/on   directly   with   doctors   to   control  
chronic  condi/ons  remotely.  

produces  an  alert  band  with  
advanced  medical  profile  
management:  by  scanning  the  
band,  you  obtain  key  medical  
informa/on  about  the  wearer  such  
as  emergency  contact,  life-­‐
threatening  condi/ons,  medical  
treatment  informa/on,  
medica/ons,  and  medical  history.  
Google  &  Novar6s  
have  teamed  up  to  license  
microchips  embedded  inside  
“smart”  contact  lenses.  By  analyzing  
the  wearer’s  tears,  the  lenses  alert  
people  with  diabetes  about  
dangerous  dips  in  their  glucose  
Given  Imaging  
has  developed  a  babery-­‐powered  
camera  pill  that  can  take  high-­‐speed  
photos  of  the  intes/nal  tract.  The  
pill  then  sends  the  images  to  a  
device  worn  by  the  pa/ent,  and  
then  to  a  computer  or  tablet  so  
doctors  can  review  them.  
Proteus  Digital  Health  
has  developed  a  system  consis/ng  
of  a  smartphone,  a  sensor  patch  
and  a  pill.  Upon  swallowing,  the  
sensor  is  ac/vated  by  electrolytes  
within  the  body.  

Trend  Report  |  Big  Data  &  Health  

Datafica/on  of  Healthcare  
Companies   also   started   inves/ng   in  
embeddable   technologies:   these   /ny  
microchips   implanted   into   or   onto   the  
human   body   not   only   monitor   but   also  
affect  the  pa/ent’s  biometrics.    
Last   but   not   least,   another   technology  
appeared   in   the   last   years:   inges/ble  
sensors,   or   smart   pills.   The   global   smart  
pills   market   is   expected   to   reach   965  
million   dollar   by   2017.   The   development   of  
this   technology   is   currently   focusing   on  
two  func/ons:  wireless  pa/ent  monitoring  
and  diagnos/c  imaging.  
Even   though   these   new   technologies   are  
revolu/onizing   healthcare,   healthcare  
actors  and  stakeholders  oken  do  not  have  
the  /me  or  the  willingness  to  adapt.  
•  The   regula/on,   first   of   all,   is   too  
slow   to   adapt   to   technological  
change   and   can   be   business  
unfriendly,   in   par/cular   when   it  
comes  to  privacy  of  data.  
•  Pa/ents  also  are  oken  in/midated  
by   these   new   technologies   or  
reluctant   to   share   their   data,   but  
need   to   be   educated   about   its  
benefits   and   need   be   aware   of  
who   is   using   their   data   and   what  
•  Finally,   some   doctors   are   also  
reluctant   to   change;   they   feel  
threatened   by   new   compe//on,  
even   though   their   profession   is  
just   being   reshaped   by   these   new  
technological   tools   and   actors  
w h i c h   r e p r e s e n t   n e w  


Today,  there  is  an  es/mated  150  exabytes  of  health  data:  the  collec/on  and  flow  of  
data   does   not   only   help   monitoring   individual   health   on   the   day-­‐to-­‐day   basis.   Big  
data   will   also   have   a   fantas/c   influence   on   medical   research   and   solu/ons:  
healthcare  and  treatments  would  not  be  based  on  averages  anymore  -­‐  as  it  is  now  -­‐  
but  on  individual  informa/on.    
Health   stakeholders   s/ll   need   to   acquaint   with   this   revolu/on,   and   this   will   take  
/me,  but  it  will  lead  to  a  more  personalized,  efficient  and  cost-­‐effec/ve  healthcare  
system.  The  different  sources  of  health  data  are  depicted  below.    

Ac6vity  and  Cost  Data  

Clinical  Data  

Integra/on  of  
data  pools  
required  for  major  

Pharmaceu6cal  R&D  

Pa6ent  Behavior    

Big   data   sources   are   mul/ple   and   will   all   contribute,   if   they   coordinate,   to   pave   a  
beber  future  for  current  healthcare  systems.  Now,  let's  see  how  big  data  will  impact  
each   stakeholder   involved   in   the   process   of   healthcare   -­‐   from   pa/ents   to   doctors,  
and  companies  to  governments.  


Trend  Report  |  Big  Data  &  Health  

The  influx  of  data  on  pa/ents  stemming  from  the  Electronic  Health  Records  (EGRs),  medical  
surveys,  or  personal  data  sources  is  an  incredible  tool  for  doctors,  allowing  them  to  provide  
safer,  more  efficient,  pa/ent-­‐centered  care.  
Tradi/onally,  healthcare  is  delivered  by  one  doctor  examining  one  pa/ent  at  a  /me,  and  the  
prac//oner   works   with   whatever   informa/on   is   available   at   the   /me   of   the   appointment.  
Now,   with   the   interven/on   of   big   data,   not   only   will   prac//oners   have   access   to   their  
pa/ents’  en/re  medical  record,  but  they  will  also  have  the  possibility  to  compare  it  with  other  
people’s  medical  records,  thus  allowing  them  to  make  a  beber  diagnosis.      
Big   data   permits   a   real   split   from   the   ‘one-­‐size-­‐fits-­‐all’   aMtude   that   is   so   common   in  
healthcare,  giving  medical  prac/ces  the  possibility  to  mold  their  approach  depending  on  an  
individual  pa/ent’s  situa/on,  with  access  to  all  the  needed  informa/on.  

More   and   more   data   is   produced,   owned   and   controlled   by   pa/ents:   we   enter   a   new   era  
where   pa/ents   can   become   increasingly   ac/ve   in   taking   care   of   their   health!   Some   savvy  
consumers   even   maintain   personal   health   records   separately   from   their   medical   services  
Indeed,  we  saw  previously  that  consumers  produce  huge  quan//es  of  personal  health  data  
by  using  an  increasing  number  of  health  monitoring  devices  and  applica/ons.  
Data  is  not  only  “passively”  collected:  many  pa/ent  communi/es  advocate  for  pa/ent  data  to  
be  shared.    
•  Pa/entsLikeMe,   for   example   is   a     health   social   media,   where   pa/ents   can   share   their  
experience  with  pa/ents  with  similar  diseases  and  medical  researchers.    
•  Crohnology   is   a   plagorm   where   pa/ent   sharing   their   data   about   the   Crohn’s   disease   to  
create  a  body  of  science  and  evidence  available  to  researchers  too.  
•  Umo/f   is   a   technology   collec/ng   quan/ta/ve   and   qualita/ve   data   through   surveys,  
sensors,  symptom  tracking  for  clinical  research.        


Many  companies  are  building  applica/ons  and  analy/cal  tools  that  help  pa/ents,  physicians  
and  other  healthcare  stakeholders  to  iden/fy  value  and  opportuni/es.  As  their  technological  
capabili/es   and   understanding   advance,   we   expect   innovators   will   develop   even   more  
interes/ng  ideas  for  using  big  data.    
Health  Data  Creators  
Medical   care   providers   (e.g.   hospitals)   and   smart   wearable   device   providers   (e.g.   Apple)  
maintain  and  supposedly  own  all  health  data  which  was  generated  by  their  various  business  
units,   as   well   as   all   copies   of   data   created   by   others   and   transmibed   to   them   during   the  
business  process.  
Insurance  Companies  
Insurance   companies   (e.g.   Allianz)   who   are   in   charge   of   the   informa/on   exchange,   such   as  
medical   claims   and   payment   data,   medica/ons,   and   to   a   lesser   extent   laboratory   data,   are  
also   accumula/ng   copies   of   whatever   informa/on   is   flowing   through   their   systems   in  
electronic  format.  
Technology  Vendors  
Technology   vendors   are   companies   who   supply   electronic   solu/ons   to   health   data   creators  
(e.g.   hospitals),   and   especially   the   vendors   who   offer   their   technology   in   a   remote   service  
model,  retain  full  access  to  their  customers  data.  

In   the   United   States,   for   example,   the   government   and   other   public   stakeholders   have  
enhanced   their   transparency   levels   by   allowing   the   en/re   healthcare   sector   to   use,   search,  
and  act  upon  data  that  has  been  stored  for  decades.  In  addi/on,  the  Italian  Medicines  Agency  
collects   and   analyzes   clinical   data   on   expensive   new   drugs   as   part   of   a   na/on-­‐wide   cost-­‐
effec/veness   program.   Based   on   the   outcome,   the   agency   may   re-­‐evaluate   prices   and  
market-­‐access  condi/ons.    


Trend  Report  |  Big  Data  &  Health  

What’s  up  Berlin?  
Berlin-­‐Brandenburg   is   known   for   being   amongst   the   leading   regions   with   life   sciences   and  
healthcare  industry  centers.  Outstanding  science  and  research  facili/es  together  with  a  broad  
range   of   business-­‐oriented   research   and   development,   create   an   ideal   infrastructure   for  
transforming  the  latest  scien/fic  findings  into  innova/ve  products  for  the  healthcare  sector,  
and  make  this  region  the  key  player  in  the  innova6on  landscape  of  Germany  and  Europe.    
Approximately   350,000   people   work   in   the   healthcare   industry   in   Berlin   and   Brandenburg,  
which   is   more   than   ⅛   of   the   region´s   total   number   of   employed   people.   Therefore,   the  
healthcare   sector   shows   a   large   contribu/on   to   employment   and   growth   in   the   region.   In  
addi/on,  the  joint  innova/on  strategy  of  Berlin  and  Brandenburg  (innoBB),  which  came  into  
existence  in  2007,  aims  to  expand  the  cluster's  development  and  drive  top  performance  for  
the  regional  and  global  healthcare  markets.    

As   a   result,   one   can   understand   the   importance   of   Berlin   as   a   hotspot   for   healthcare  
innova6on   and   therefore,   the   importance   for   startups   to   establish   their   headquarters   in  
Berlin;  the  city  is  full  of  opportuni6es  and  acceptance.  Also,  it  is  rather  easy  for  digital  health  
startups  to  connect  with  policy  makers  in  the  healthcare  industry,  since  health  economics  are  
preby  much  interwoven  with  health  policies.  
According   to   Juliane   Zielonka   from   Startupbootcamp   Digital   Health,   Berlin   has   35   large  
research  ins/tutes  and  universi/es  focusing  on  life  sciences.  For  digital  health  startups,  this  is  
very   beneficial   as   it   allows   access   to   a   network   of   qualified   researchers,   a   great   test   ground  
for  prototyping,  and  a  large  pool  of  employable  research  and  development  teams.  Accurate  
laws   protect   businesses   and   entrepreneurs   and   further   policy   changes   are   in   mo/on.  
According  to  McKinsey,  the  city  of  Berlin  is  expected  to  create  100,000  new  jobs  by  2020.    

Trend  Report  |  Big  Data  &  Health  

In  general,  Berlin  is  an  excellent  loca6on  both  for  businesses  and  individuals  
as  its  culture  inspires  crea6vity  and  open-­‐mindedness  to  ideas.  The  growing  
economy,   the   growing   number   of   jobs   and   the   interna6onal   environment  
contribute  to  the  city’s  energy  that  is  famous  across  the  globe.  In  addi/on,  the  
capital   boasts   a   cultural   landscape   that   is   unique   within   Germany.   Berlin   offers  
a  high  quality  of  life,  yet  is  at  the  same  /me  very  affordable  for  anyone.  Also,  
the  EU  Commission  named  Berlin  “Access  City  2013”  and  awarded  the  city  for  
its  dedica/on  of  removing  barriers.      
Currently,   300   medical   technology   companies,   more   than   240   biotech  
companies,   30   pharmaceu/cal   manufacturers,   and   more   than   130   hospitals  
have  chosen  Berlin  as  their  premier  loca/on.  That  is  not  without  reason;  Berlin  
is  known  for  its  culture  of  crea/veness  and  co-­‐crea/on.  The  city  contains  many  
co-­‐working   spaces   where   people   connect   and   work   together,   but   also   many  
accelerators   which   provide   startups   with   access   to   resources,   professional  
networks  and  mentors.    
All   of   these   factors   together   make   Berlin   very   abrac/ve   for   Venture   Capital  
firms  and  other  investors.    According  to  Pitchbook,  an  M&A,  Private  Equity  and  
Venture  Capital  Database,  there  are  159  healthcare  startups  in  Germany  which  
have  been  founded  since  2008.  In  Berlin  and  Potsdam,  37  healthcare  startups  
with   a   founding   date   since   2008   are   registered   in   the   Pitchbook   database.  
However,   Pitchbook   is   only   one   source   and   a   rather   young   source,   and   it   is  
possible  that  more  mature  databases  show  addi/onal  healthcare  startups.    

As   men/oned   before,   37   (digital)  
healthcare   startups   can   be   found   in  
the   Pitchbook   database   with   a  
founding   date   since   2008   and   are  
based   in   Berlin   or   Potsdam.   As   can   be  
depicted  in  the  graph  below,  the  total  
deal  counts  (fundings  into  Berlin-­‐  and  
Potsdam-­‐based   healthcare   startups)  
has   stayed   rather   constant   between  
2013  and  2016.  Total  capital  invested,  
however,   was   $17M   with   11   deal  
counts   in   2014.   In   2016,   total   capital  
invested   was   $7M   with   11   deal  
counts.  From  this  is  can  be  concluded  
that   one   or   a   few   par/cular  
healthcare   startups   have   raised   a  
significant  amount  of  funding  in  2014  
and   startups   have   received   less  
funding  in  2016.    

A  result  of  this  is  that  not  all  healthcare  startups  in  Berlin  have  been  registered  
on  the  Pitchbook  plagorm,  because  some  might  be  too  small  to  be  able  to  be  
found,  others  operate  as  a  startup  of  a  larger  corporate  and  cannot  be  found  
separately,  and  yet  others  might  be  registered  in  another  place  than  Berlin  and  
are  therefore  harder  to  find.  Furthermore,  it  is  rather  difficult  to  classify  what  a  
digital   healthcare   startup   is   and   what   not   in   databases   like   Crunchbase   and  
Do   we   consider   surgical   hardware   startups   amongst   healthcare   startups   or  
amongst   IT   hardware   startups?   Nonetheless,   we   have   used   Pitchbook   as   a  
source  to  gather  informa/on  on  successful  players  in  Berlin  to  provide  a  more  
detailed  overview  of  the  Berlin  industry  landscape  of  (digital)  healthcare.    



Trend  Report  |  Big  Data  &  Health  

Berlin’s  Health  Champions  
Among  those  37  startups,  the  ones  that  have  received  the  most  funding  since  their  
founda/on  date  are  the  following  three.  

MEDIGO,   founded   in   2013,   is   medical   travel   made  
simple.   It   is   a   curated   marketplace   that   simplifies   the  
complex   process   of   booking   medical   travel.   MEDIGO  
aims   to   disrupt   the   en/re   healthcare   industry   by  
helping   pa/ents   who   desire   affordable   treatment,  
access   to   higher   quality   facili/es   or   doctors,   or   who  
want  to  drama/cally  cut  wai/ng  /mes.  Pa/ents  search  
for   hospitals   or   clinics,   book   procedures   and   arrange  
medical  travel  online.  The  plagorm  is  completely  free-­‐
to-­‐use  and  is  currently  available  in  5  languages:  English,  
German,   Spanish,   Italian,   and   French.   Currently,   there  
are   nearly   400   high   quality,   interna/onally-­‐accredited  
hospitals  and  clinics  in  more  than  15  countries  listed  on  
the   plagorm.   MEDIGO   has   received   a   total   funding   of  
$11.83M   in   six   rounds   from   six   investors   according   to  
Fiagon   AG   medical   technologies,   founded   in   2009,  
develops   and   manufactures   innova/ve   surgical  
naviga/on   systems   of   the   latest   genera/on   with   its  
proprietary   “Flexsensor”   technology.   In   the   last   years  
Fiagon,   along   with   world-­‐renowned   physicians,   has  
changed   the   standard   in   ENT   naviga/on   with   its  
proprietary   naviga/on   technology.     And   this   unique  
technology   is   expected   to   also   be   very   useful   in   oral  
and   maxillofacial   surgery,   neurosurgery,   and   spine  
surgery.  Fiagon  has  received  a  total  funding  of  $7.5M  in  
one  round  from  two  investors.    
Clue,   founded   in   2013,   is   one   of   the   most   successful  
actors   in   the   field   of   digital   female   health,   currently  
offering  the  world’s  fastest  growing  period  tracker  and  
fer/lity   app.   The   app   is   based   on   an   algorithm,  
calcula/ng   and   predic/ng   the   user’s   individual   and  
unique   cycle.   Hence,   the   more   it   is   used   the   more  
accurate   it   gets.   Besides   a   visual   representa/on   of  
period,   fer/le   window   and   premenstrual   syndrome,  
the   app   also   offers   educa/onal   material   around   female  
cycles,  pregnancy  and  PMS.  Aker  its  series  A  funding  in  
October  2015,  Clue  received  $7  million  and  has  grown  
its   App   to   currently   encompass   more   than   five   million  
users   and   being   offered   the   app   stores   of   more   than  
100  countries.    

Today’s  Rising  Actors  

Several   rising   actors   in   the   Berlin   ecosystem   enable   the   city´s   future   prosperity   in  
(digital)  health.  

Ralph  has  been  very  
suppor/ve  to  us  and  
connected  us  to  several  
interes/ng  companies  in  
the  Digital  health  
ecosystem  and  
introduced  us  to  several  
hot-­‐topics  and  
interes/ng  startups  in  
this  field.    

Startupbootcamp  Digital  Health  
Berlin,    founded  in  2016,  is  an  
accelerator  that  supports  innova/ve  
startups  that  combine  medical  
knowledge  with  smart  technologies,  
with  a  special  focus  on  behavior  
change,  diagnos/cs  and  genomics,  big  
data  and  analy/cs.  They  provide  
mentorship,  funding,  logis/c  support  
and  access  to  their  huge  network  of  
industry  specific  mentors,  corporate  
partners,  angels  and  VC’s  to  up  to  10  
high  poten/al  Digital  Health  startups  
from  around  the  world  over  a  period  of  
3  months.  In  return,  they  request  6  
percent  equity.    

 Ralph  Arnold,  is  one  of  Berlin’s  
premier  experts  on  digital  health  and  
an  ac/ve  angel  investor  with  his  
Jenseits  Ventures  and  a  mentor  at  
startupbootcamp  and  hub:raum.  
Simultaneously,  he  is  a  Co-­‐Founder  
and  Managing  Director  at  TransAct  
Advisory  Services,  which  supports  its  
clients  in  transac/ons  based  in  the  
Healthcare  sector.  Ralph  Arnold’s  
exper/se  stems  from  his  M&A  
experience  both  in  the  banking  and  
pharmaceu/cal  sector  as  well  as  his  
/me  as  Managing  Director  Bayer  
Innova/on,  the  venture  capital  and  
new  business  venture  unit  at  Bayer  AG.  
Ralph  has  lived  and  worked  in  
Germany,  USA,  UK,  France,  Brazil  and  
Portugal.  He  holds  an  MBA  from  
Columbia  University.  

We  have  had  contact  
with  Marius  
Oesterschlink,  who  
introduced  us  to  several  
startup  founders  in  the  
Berlin  ecosystem.    


Trend  Report  |  Big  Data  &  Health  

We  have  had  a  phone  
conversa/on  with  
Norman  Krüger  to  get  a  
general  introduc/on  on  

xBird,  founded  in  2015  in  Berlin,  is  a  
medical  AI  company  dedicated  to  save  
lives  by  disrup/ng  the  way  we  think  
about  preven/on  and  early  detec/on  
of  diseases.  xBird  is  developing  
sophis/cated  machine  learning  
algorithms  that  analyze  sensor  data  
from  smartphones  and  wearables  to  
predict  and  prevent  cri/cal  health  
risks.  The  company  consists  of  medical  
doctors,  data  scien/sts  and  serial  
entrepreneurs  from  Berlin  and  Silicon  
Valley.  xBird  is  currently  part  of  the  
Grants4Apps  accelerator.    

We  have  had  contact  
with  Jörg  Land  to  present  
Tinnitracks  at  our  
Fes/val  exhibi/on  about  
digital  health.  


Coronect,  founded  in  2016  in  Berlin,  
develops  an  innova/ve  medical  grade  
product  which,  with  its  patent  pending  
technology,  measures  a  
comprehensive  5  channel  ECG/EKG.  
With  its  easy  to  use  and  comfortable  
chest  strap,  data  is  collected  and  sent  
to  a  secure  cloud.  On  request  their  
expert  team  of  cardiologists  creates  a  
personal  detailed  report  about  the  
general  condi/on  the  heart  is  in,  as  
well  as  tailored  hints  on  how  to  
improve  upon  it  to  further  beber  the  
quality  of  life.  

We  have  had  contact  
with  Sebas/an  Sujka  and  
we  have  seen  the  xBird  
office  during  our  mee/ng  
with  Grants4Apps.  

Sonormed,  founded  in  2012,  is  an  
Hamburg  based  startup  which  tries  to  
make  people  hear  beber  by  addressing  
their  hearing  problems  with  everyday  
consumer  electronics.  In  their  first  
successful  abempt,  they  developed  the  
App  Tinnitracks  which  helps  alleviate  
the  pains  and  distrac/ons  of  /nnitus.  
Sonormed  was  able  to  strike  first  deals  
with  German  public  insurances  to  
allow  users  to  be  reimbursed  for  their  
purchase  of  the  paid  app  version  and  
further  cooperates  with  the  
Fraunhofer  Insitute  and  Sennheiser  in  
the  development  and  improvement  of  
its  technology.  

Emperra,  founded  in  2008,  already  
established  their  products  along  the  
en/re  line  of  repor/ng  of  blood  sugar  
and  insulin  values  from  the  pa/ent  to  
the  doctor.  The  products  are  branded  
as  Esysta  and  are  based  around  the  
company’s  in  house  insulin  pen  with  
advanced  communica/on  capabili/es,  
either  Bluetooth  or  GSM,  and  the  
company’s  online  app  and  online  
portal  for  quick  and  easy  analysis.  This  
allows  the  user  to  quickly  recognize  
incorrect  dosing  of  his  insulin  
injec/ons,  coupled  with  quick  
communica/on  between  physician  and  

We  have  had  contact  
with  Marius  
Oesterschlink,  who  
introduced  us  to  several  
startup  founders  in  the  
Berlin  ecosystem.    

Grants4Apps,  founded  in  2014,  is  the  
in  house  accelerator  of  Bayer  
Healthcare  and  part  of  the  division’s  
open  innova/on  ini/a/ve,  enabling  
Bayer  to  create  an  environment  in  
which  to  advance  digital  innova/on  in  
health  care.  The  Grant4Apps  program  
offers  five  addi/onal  loca/ons  besides  
Berlin,  e.g.  Shanghai  and  Moscow.  
Within  the  program  start  ups  receive  
intensive  mentoring  from  internal  and  
external  experts,  opera/onal  support  
in  form  of  €50.000  and  office  space  for  
100  days  as  well  as  an  entry  to  the  
extensive  network  Bayer  Healthcare.  

We  interacted  with  dr.  
Chris/an  Krey  to  provide  
us  with  material  for  the  

XLHEALTH  is  a  Berlin-­‐based  Venture  
Capital  investor  in  startups  of  the  IT  
healthcare  industry.  Following  the  
mission  statement  "Digital  Health  –  
Made  in  Germany"  XLHEALTH  invests  
in  selected  companies  that  make  a  
sustainable  impact  to  preserve  and  
improve  human  health.  XLHEALTH  
offers  startups  a  network  of  mentors  
and  access  to  400,000  providers,  
organiza/ons,  industry  partners  and  
patented  health  technologies.  

We  visited  Grants4Apps  
where  Jesus  del  Valle  
and  Jannis  Busch  
presented  the  cohort  of  
2016,  and  the  
possibili/es  and  scope  of  
current  and  past  
ventures  they  supported.  


Trend  Report  |  Big  Data  &  Health  


Of  all  the  different  projects  we  came  across  whilst  inves/ga/ng  the  field  of  
medical   technology,   or   “meditech”,   one   par/cularly   caught   our   aben/on:  
Teddy   the   Guardian.   Teddy   the   Guardian   is   a   Croa/an   start-­‐up  
headquartered   in   London,   founded   by   two   young   students   in   2013.   It  
commercializes   the   first   ‘smart’   Teddy   Bear,   whose   mission   is   to   monitor  
children’s   health   on   a   daily   basis   and   collect   vital   informa/on,   through  
captors   hidden   in   the   toy.   The   collected   data   is   then   compiled   and   sent   to  
the  parents,  through  a  dedicated  mobile  app.  


Trend  Report  |  Big  Data  &  Health  

The  Story  of  Teddy  
The   idea   for   Teddy   the   Guardian   first   came   when   its   creators   no/ced   how  
hard  it  was  to  monitor  the  health  of  children  who  were  being  hospitalized  or  
treated   for   chronic   illnesses,   in   a   non-­‐frightening   and   intrusive   way.   Lible  
ones  tend  to  be  extremely  sensi/ve,  and  the  careful  monitoring  some  were  
being   subjected   to   in   the   hospital   meant   that   a   solu/on   needed   to   be   found  
in  order  to  make  the  monitoring  less  trauma/c.  Making  smart  Teddy  Bears  
came   as   the   way   to   go,   and   the   start-­‐up   started   working   with   hospitals   to  
develop  its  product.    

Another   important   trigger   in   the   development   of   Teddy   The   Guardian   was  
the   fall   of   sensor   costs,   and   the   growth   in   wireless   communica/on   and  
constant  innova/on,  which  have  made  this  project  accessible  and  possible  to  
develop.   Furthermore,   it   has   never   been   easier   to   appeal   to   consumers   in  
this  field,  since  smartphones,  health  mobile  apps  and  wearable  devices  are  
geMng   every   day   more   and   more   integrated   in   their   daily   lives.   Hence,   it  
soon  became  obvious  that  Teddy  could  also  be  commercialized  to  the  public,  
and  not  only  to  hospitals.  
Indeed,   parents,   as   the   rest   of   the   popula/on,   are   proving   ever   more  
connected   and   worried   about   their   children’s   health,   and   such   a   device  
could  be  a  precious  ally  for  them.  Finally,  the  field  of  meditech  is  booming  
and  raises  growing  interest  in  investors,  who  are  now  more  and  more  willing  
to  invest.  

Behind  the  Fur  
Teddy   The   Guardian   lies   on   a   fairly  
simple   technology:   embedded  
sensors,   hidden   in   the   teddy’s  
paw,   which   measure   the   child’s  
body   temperature,   heart   rate,  
blood   pressure,   oxygen   satura/on  
and   the   ambient   temperature.  
When   the   child   squeezes   the  
teddy’s   paws,   hold   it   against   him  
or   plays   with   it,   the   bear   records  
informa/on   at   different   /mes,   and  
sends   it   wirelessly   to   his   parents  
via  a  mobile  app.    

Through   the   app,   the   parents  
can  see  the  evolu/on  of  their  
child’s   temperature   in   real-­‐
/me,   and   quickly   detect   any  
irregulari/es.   Moreover,   the  
child’s   body   temperature   can  
be   precisely   measured   by  
touching   his   forehead   with  
the   teddy’s   paw   for   a   couple  
of   seconds,   which   results   less  
unpleasant   for   them   than   the  
old  fashion  thermometer!  

Just  like  every  meditech  startup,  Teddy  The  Guardian  faced  issues  in  securing  
quality   and   regulatory   standards   in   all   countries.   It   however   managed   to  
overcome   this   and   can   now   be   shipped   across   Europe.   The   app   is   also  
available  in  all  European  countries.  
Teddy   the   Guardian   made   its   debut   at   the   CES   conference   of   Las   Vegas   in  
2014.   The   CES   conference   is   a   global   consumer   electronics   and   consumer  
technology   tradeshow.   There,   it   triggered   a   lot   of   interest   and   was   very   well  
received   by   the   professionals,   who   praised   its   simplicity   and   its   ingenuity.  
Teddy  the  Guardian  is  now  considered  as  one  of  the  hits  of  the  2014  edi/on.  
Following   this   success,   it   secured   a   400k   seed   investment   from   London-­‐
based   investors   in   January   2015.   This   allowed   the   startup   to   further   develop  
its   offer,   and   in   2016,   two   new   companions   were   introduced:     The   Tall  
Giraffe   and   The   Brave   Lion.   The   Tall   Giraffe   measures   the   child’s   body  
posture   and   ac/vity   level,   and   the   Brave   Lion   measures   the   heart   rate,   heart  
rate  variability  and  blood  oxygen  satura/on.  

Trend  Report  |  Big  Data  &  Health  

Special  Thanks  
This   trend   report   was   created   during   the   explora/on   phase   of   Op/onE   at   the   ESCP   Europe  
Berlin  campus,  ensuring  us  the  support  of  many  amazing  people.  Out  of  all  of  those,  we  would  
like   to   specifically   thank   three   people   that   were   integral   to   this   report   and   the   organiza/on   of  
our  presence  at  the  Entrepreneurship  Fes/val  at  ESCP  Europe.  
First  and  foremost  we  would  like  to  thank  the  director  of  our  specializa/on,  Rene  Mauer,  for  
establishing   the   Op/onE   at   the   Berlin   campus   end   giving   us   the   chance   to   dive   into   this  
exci/ng  and  ever  changing  environment.  
Once  we  arrived,  Gunnar  Graef,  French  Tech  Ambassador  and  Investor  based  in  Berlin,    helped  
us  navigate  through  Berlin’s  start  up  ecosystem,  taking  us  by  the  hand  and  introducing  us  to  
many  experts  and  important  actors.  His  Safari  trip  at  the  beginning  of  our  program  paved  the  
way  for  our  following  explora/on  phase  and  countless  interviews  and  collabora/ons  with  local  
Among  those  was  Ralph  Arnold,  who  we,  last  but  not  least,  would  like  to  express  our  gra/tude  
to  for  taking  the  /me  to  support  us  with  his  insights  and  contacts  in  the  digital  health  market  
in  Berlin  and  beyond,  introducing  us  to  several  of  the  companies  men/oned  in  this  report.  

What’s  up  in  the  French  Tech  Ecosystem?  
For   some   years   now,   the   French   Tech   ecosystem   has   seen   rapid   growth,   driven   by   a   new  
genera/on   of   entrepreneurs,   investors,   engineers,   designers,   and   other   talents.   France   is  
becoming   a   “startup   Na/on”,   home   to   vibrant   tech   hubs   and   talent,   and   driven   by   a   strong  
entrepreneurial  culture.  Paris  in  specific,  is  a  world-­‐class  venue  for  startups.    Currently,  Paris  is  
the  number  one  in  Europe  for  the  growth  of  its  innova/on  market,  and  it  is  among  the  top  six  
tech  ci/es  in  the  world.    
Several  actors  in  France  enable  the  country’s  advancement  in  Digital  health:  64  life  science  
startups  listed  on  the  Euronext  Paris  stock  exchange  and  three  NASDAQ  IPOs  in  less  than  a  year  

Special  thanks  to:  This  report  has  been  prepared  by  interna/onal  graduate  students  of  ESCP  
Maximilian  TraugoA,  Ruibo  Wu,  Joy  de  Bausset-­‐Roquefort  Duchaine  D’Arbaud,    
Tyrza  Nanlohij,  Maïa  Bilhou-­‐Nabera  
Prof.  Gunnar  Gräf,  Partner  of  Deutsche  Ventures  and  Affiliate  Professor  at  ESCP  Europe  
Prof.  René  Mauer  ,  Chair  for  Innova6on  and  Entrepreneurship  ESCP  Europe  

A  coopera)on  between  

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