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BIOTOXIN PROTOCOL.pdf2082363964 (2).pdf


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Page 13
Patients should blow their nose to remove mucus, dust or debris prior to
administration of VIP into the nostrils.
Treating Capillary Hypoperfusion-VO2 Max (post exertional malaise)

With high cytokine levels and often low VEGF levels, Biotoxin patients may have
lower threshold for hypoxia than other people. These patients still need to exercise
to improve oxygenation to their cells. The key is to have these patients stay below
their anaerobic threshold to prevent depletion of glycogen stores.
Perform a cardiopulmonary stress test to determine anaerobic threshold by
measuring VO2 max. O2 uptake and CO2 output are measured.
If VO2 max is >35- Normal
<20 Some biotoxin illness patients
12-15 Stage IV CHF
Treatment options to improve Hypoperfusion
Graded exercise that stays below the patient’s anaerobic threshold.
Correction of low VEGF
Procrit and VIP- can increase VO2max (protocol in manual)

Extra information:
The HPA (Hypothalamic-piuitary adrenal) axis is an area that can be dysregulated in
Biotoxin Illness. Normally the hypothalamus axis is tightly regulated. The peptide
hormone known as CRH stimulates the release of ACTH (adrenocorticotropic
hormone) from the anterior pituitary gland. ACTH signals cortisol production in the
adrenal glands. Sufficient cortisol directly suppresses further release of CRH from
the hypothalamus and ACTH from the anterior pituitary gland. Cortisol is normally
tightly regulated and released in response to stress. It gives a good reflection of how
the neuroendocrine system is working. Cortisol regulation is lost in 50% of patients
with low MSH. Early in Biotoxin illness and as patient’s improve with treatment,
high ACTH and cortisol levels are seen when measured simultaneously.
Early in illness and as MSH begins to fall, high ACTH is associated with few
symptoms; a marked increase in symptoms is associated with a fall in ACTH.
Patients who are very ill can have an ACTH and cortisol levels that are also very low.
In early illness or patients who are improving with treatment ACTH and cortisol can
be high. If not improving rule out tumor.
Normal regulation: ACTH is high and Cortisol is low

See end of treatment and follow up care in protocol manual