Abstracts from CIPP XVI Meeting Libon june 2017.pdf

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children, the weaning of LTOT was possible after COO and no


children needed to resume the therapy. The frequency of clinical

This prospective study evaluated the acute effects of a single session

evaluations changed according to disease stage: every two months

of WPS on LCI. Due to ethical concerns, the study was performed only

before oxygen withdrawal, monthly immediately after oxygen

in adults.

withdrawal and then every three months.

The primary outcome parameter was the change in LCI.
Carboxyhemoglobin (COHb) levels, pulmonary function tests and


vital signs were evaluated in volunteer WPS group smokers before and
Domiciliary COO can provide relevant information in the weaning of

after 30 min of WPS session.

supplemental oxygen in BPD patients, leading to a confirmation of
clinical findings. A spot oximetry cannot cover all critical times of the
day and night, such as all sleep stages.

26 volunteers (21 men, 5 women), aged 25.6 ± 4.88 years, were
recruited. Following one session of WPS, LCI values did not change
(6.52 lit ± 0.83 vs. 6.30 lit ± 0.66, p = 0.22). COHb levels rose
significantly, from 2.66% ± 1.61% (median 2.35) to 10.28% ± 4.42%

#N192 − The Evaluation of the Acute Effect of a Single Use

(median 9.80), p < 0.001. Heart rates increased from 86.5 ± 12.67

of Waterpipe Smoking on Lung Clearance Index.

beats/min (median 83) to 92.92 ± 17.04 beats/min (median 91.5), p

Toukan Y


, Bentur L1, Hakim F 1; Elemy A2.


Pediatric Pulmonary Institute and CF Center, Ruth Rappaport Children’s Hospital,
Rambam Health Care Campus − Haifa, Israel; 2Department of Pediatrics A, Ruth
Rappaport Children’s Hospital, Rambam Health Care Campus − Haifa, Israel

< 0.05. Respiratory rate increased from 14.85 ± 2.01 breaths/min to
19.39 ± 4.97 breaths/min, p < 0.001. There was a significant decrease
in both FEV1/FVC and FEF 25%-75%.
This first study evaluated the effect of WPS on LCI. In this small sample


size, no significant changes in LCI values after one session of WPS

Waterpipe smoking (WPS) has been spreading steadily from Eastern to

were noted. Further larger studies evaluating the possible effect of

Western countries especially among teenagers. A single session of

WPS on LCI measurements with multiple clinical and physiological

WPS increases the levels of carboxyhemoglobin (COHb) in the blood,

parameters should be performed to assess the clinical benefit of LCI

has a negative effect on cardiopulmonary parameters, and a

measurement in WPS subjects.

controversial effect on lung function indices. Lung clearance index
(LCI), an index of ventilation inhomogeneity, has not been evaluated in
WPS subjects.

How to cite this article: Abstracts from CIPP XVI Meeting.


Pediatric Pulmonology. 2017;52:S100–S176.

To evaluate the acute effect of a single 30-minute session of WPS


on LCI.