Research Engineer Postdoc Human cell biology CEA Saclay 2017 .pdf


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Research Engineer / Post-doctoral Position – Human cell biology
New mechanisms of nucleotide excision DNA repair coupled with transcription activation
in human cells
A 30-month research engineer position funded by the Fondation ARC is open from
November 2017 to work in the group “Genome Transcriptional Regulation” headed by Dr.
Julie Soutourina at the Institute for Integrative Biology of the Cell (I2BC), Integrative
Biology and Molecular Genetics Unit (SBIGeM) on the Saclay campus of the CEA (Paris
region, France).
The research engineer/post-doctoral fellow will be in charge of the part of the on-going
project on the new mechanisms of nucleotide excision DNA repair coupled with
transcription activation using human cells as a model system. The project is based on our
recent discovery of a novel Mediator role in transcription-coupled DNA repair. We aim to
develop new concepts of the functional interplay between transcription and DNA repair, two
fundamental processes, dysfunctions of which lead to serious human diseases including
cancer.
The successful candidate will have a PhD in molecular biology with solid background
knowledge in genetics and functional genomics. A prior experience in human cell biology is
strongly required. We are seeking for highly motivated candidates interested in the
deciphering how transcription and DNA repair are coordinated in human cells on the genomic
scale. A previous experience in ChIP-sequencing approaches will be appreciated.
Interested candidates should contact Dr. Julie Soutourina at julie.soutourina@cea.fr and send
a Curriculum Vitae, including past research experience and publication records, as well as a
letter detailing their motivation and interest in our work. Applicants should also provide the
names and contact details for two or three references and recommendation letters.
Websites: http://ibitecs.cea.fr/drf/ibitecs/Pages/services/sbigem/ltg/regulation-transcriptionnelle-genomes.aspx
and http://www.i2bc.paris-saclay.fr/spip.php?article395.

Selected references of the group:
Eychenne T., Novikova E., Barrault M.-B., Alibert O., Boschiero C., Peixeiro N., Cornu D., Redeker V., Kuras
L., Nicolas P., Werner M., & Soutourina J. (2016) Functional interplay between Mediator and TFIIB in
preinitiation complex assembly in relation to promoter architecture. Genes & Dev. 30, 2119-2132.
Eyboulet F., Wydau-Dematteis S., Eychenne T., Alibert O., Neil H., Boschiero C., Nevers M.-C., Volland H.,
Cornu D., Redeker V., Werner M., & Soutourina J. (2015) Mediator independently orchestrates multiple steps
of preinitiation complex assembly in vivo. Nucleic Acids Res. 43(19), 9214-9231.
Eyboulet F., Cibot C., Eychenne T., Neil H., Alibert O., Werner M. & Soutourina J. (2013) Mediator links
transcription and DNA repair by facilitating Rad2/XPG recruitment. Genes & Dev. 27, 2549-2562.
Carrière et al. (2012) Genomic binding of Pol III transcription machinery and relationship with TFIIS
transcription factor distribution in mouse embryonic stem cells. Nucleic Acids Res. 40, 270-283.
Soutourina, J. et al. (2011) Direct RNA polymérase II – Mediator interaction required for transcription in vivo.
Science 331, 1451-1454.
French Alternative Energies and Atomic Energy Commission (CEA)
Saclay Center ⏐ 91191 Gif-sur-Yvette Cedex
T. +33 (0)1 69 08 54 13 ⏐ F. +33 (0)1 69 08 47 12
julie.soutourina@cea.fr

Fundamental Research Division
Institute of Life Sciences Frédéric Joliot
Integrative biology and molecular genetics unit
Institute for Integrative Biology of the Cell
Genome Biology Department


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