Fichier PDF

Partage, hébergement, conversion et archivage facile de documents au format PDF

Partager un fichier Mes fichiers Convertir un fichier Boite à outils PDF Recherche PDF Aide Contact



Annonce postdoc ou CDD ingénieur .pdf


Nom original: Annonce postdoc ou CDD ingénieur.pdf
Auteur: dlechardeur

Ce document au format PDF 1.5 a été généré par Microsoft® Word 2010, et a été envoyé sur fichier-pdf.fr le 12/01/2018 à 11:55, depuis l'adresse IP 157.136.x.x. La présente page de téléchargement du fichier a été vue 673 fois.
Taille du document: 81 Ko (1 page).
Confidentialité: fichier public




Télécharger le fichier (PDF)









Aperçu du document


Post-Doctoral position. Study of heme stress sensing and detoxification by pathogens
PROJECT OUTLINES
Our work focuses on mechanisms of heme recognition, signaling and utilization in two major
opportunist pathogens; Group B Streptococcus (GBS), which is responsible for neonatal sepsis, and
Staphylococcus aureus, a leading cause of nosocomial infections. Our aim is to understand the
molecular basis of host-pathogen relationship mediated by the heme-iron molecule and its impact on
pathogenesis.
Heme (the blood hemoglobin cofactor) is a vital but toxic molecule for nearly all organisms. When
numerous Gram-positive pathogens are confronted with blood-heme during infection, they respond by
inducing expression of a detoxification system comprising a heme efflux transporter HrtBA regulated
by a heme-sensing system HssRS. HssS is a membrane exogenous heme sensor, and HssR, a
transcriptional regulator of hrtBA. As heme-engorged bacteria are attenuated for virulence, blocking
the heme-dependent HssS response inhibition would limit infection within their host.
The project objectives are to: i) elucidate the mechanisms of HssS activation in S. aureus and GBS
(heme recognition, conditions and cofactors of expression); ii) get insights into the mechanisms of
heme efflux by HrtBA (role of the membrane, heme-binding domains); iii) screen a chemical library
for S. aureus HssS inhibitors.
PROFILE
We are looking for a highly motivated, talented and rigorous candidate. Applicants should have a PhD
in biological science and are expected to have a strong background in biochemistry and molecular
biology and experience in pathogen microbiology. Expertise in membrane protein biology would be
useful. Good communication skills (both written and oral in French and/or English) are a must.
LOCATION
Our group is part of the «MicrobAdapt» team, which studies mechanisms allowing pathogens to adapt
to host environments. The candidate will be supervised by a senior scientist (D. Lechardeur) and will
work closely with a PhD student. The post-doc will be part of a collaborative project involving
scientists from the Pasteur Institute (Paris) and the CEA (Commissariat à l’Energie Atomique et aux
Energies renouvelables) (Cadarache).
The MICALIS Institute is one of the largest Microbiology Research centers in France. It consists of 21
research teams and state-of-the-art core facilities. The group and host institute, located in Jouy-enJosas near Paris, will provide a dynamic and interactive environment.
Visit our web: www.micalis.fr/micalis_eng/Micalis-Institute or www.inra.fr
FINANCIAL SUPPORT
Funding: The position is funded by The French National Research Agency (ANR).
Beginning: Between January and March 2018.
Durée du contrat/Length of contract: 2 years.
Organization: INRA.
Applicants should send a cover letter summarizing past experience and research interests and a CV
including the names and contact information of 2 to 3 references to Delphine Lechardeur
(delphine.lechardeur@inra.fr)


Aperçu du document Annonce postdoc ou CDD ingénieur.pdf - page 1/1

Documents similaires


Fichier PDF annonce postdoc ou cdd ingenieur
Fichier PDF post doc cryo em institutcurie 2017
Fichier PDF postdoc ad duharcourt
Fichier PDF phd2018
Fichier PDF postdoc institutcurie biocell 2017
Fichier PDF research engineer postdoc human cell biology cea saclay 2017


Sur le même sujet..