BIOINFO Curie intronic polyadenylation .pdf


Nom original: BIOINFO_Curie_intronic polyadenylation.pdf
Auteur: Martin Dutertre

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Engineer or postdoctoral position in Bioinformatics
Institut Curie (Paris area, France)
Genome-wide analysis of intronic polyadenylation in cancer

Project
We are seeking a postdoc or engineer in bioinformatics to study the genome-wide regulation of
intronic polyadenylation in cancer development and therapy. Our recent data show large-scale
regulation of intronic polyadenylation (a poorly studied type of alternative splicing and
polyadenylation leading to alternative last exons) in several aspects of cancer development and
response to anticancer agents (Dutertre et al., Nat. Comm. 2014; unpublished data).
The recruited bioinformatician will analyze and integrate various 3’-seq (RNA-seq focused on RNA
3’-ends) and CLIP-seq data sets, using pipelines that we developed, and will develop analyses of
intronic polyadenylation in both classical and long-read RNA-seq.
Keywords: Alternative polyadenylation - Alternative splicing - Cancer - RNA-seq - CLIP-seq.

Host labs and institute
The recruited bioinformatician will work at the interface of S. Vagner’s and N. Servant’s groups,
both of which are part of Institut Curie. S. Vagner’s lab is a biology research lab focusing on RNA
biology (post-transcriptional regulation, noncoding RNAs and RNA-binding proteins) in cancer. N.
Servant’s group is part of the bioinformatics and biostatistics department of the institute, and is
dedicated to high-throughput sequencing data analysis.
Institut Curie is an internationally renowned foundation located in the Paris area (France) and
devoted to cancer care and research (from physics to biology to clinics). With more than 80
nationalities at Institut Curie, English is the commonly used language in the labs and institute.

Required skills
The candidate must hold a Master’s or PhD degree. Strong skills in bioinformatics are required. Skills
in RNA-seq data analysis and a good understanding of gene expression are strongly desired.

Practical informations
Start date: As soon as possible.
Duration: One-year salary is available. Applications for longer salary are ongoing. Candidates with a
PhD will be encouraged to apply for a postdoctoral fellowship for 2 or 3 additional years.
Supervisor: Martin DUTERTRE (PhD, permanent researcher)
Application: Send CV, motivation letter and 2 letters of support to martin.dutertre@curie.fr and
Nicolas.Servant@curie.fr


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