Professeur Hamonet ECNE 10 00337.pdf


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Ehlers-Danlos Syndrome (EDS) - Contribution to Clinical Diagnosis - A Prospective Study of 853 Patients
430

The second group (GM group), examined by the same team, is composed of 206 patients consulting in general or specialty medicine,

for a pathology other than Ehlers-Danlos syndrome. In this group, the mean age is 55.3 years ± 16, at; it includes 109 men and 97 women
(W / M ratio: 0.9). The extreme ages are 5 years old and 92 years old.

The third group (control group) is composed of 826 last persons examined from a cohort of 3,528 tertiary sector employees, during

a systematic occupational health consultation. In this group, the average age is 31.4 years ± 8.3. It comprises 408 men and 418 women
(W/ M ratio: 1.0). The extreme ages are 20 and 62 years old. We identified three individuals with a significant EDS symptomatology in
this group.

Sign

EDS

MGS

OM

Fatigue

97%

14%

7%

Finesse and skin transparency

94%

Hypermobility
Arthralgia

Sleeping problems

Dys-proprioception

Meno/metrorhaggia
Myalgia / cramps

Cutaneous Hemmoraghes
Migraines or headaches
Visual fatigue

(Sub)-luxations

Plantar Contractions
Dyspnea

Temperature dysregulation
Hyperacousia

Increased skin stretching
Genital hemorrages

Sprains or pseudo-sprains
Attention deficit

Pseudo-Raynaud phenomenon
Difficulty scarring

Cutaneous hyperesthesia
Genitale pain

Abdominal pain

Gastroesophageal reflux
Meteorism

Hyperhidrosis

Decreased working memory capacity
Upper respiratory infections
Hyperosmia
Vertigo

95%

95%

90%

4%

19%
5%

7%

3%

2%

13%

26%

87%

11%

0%

83%

6%

89%

87%

86%

83%

82%

82%

1%

13%
4%

5%

1%

3%

82%

11%

79%

1%

80%

79%

78%

78%
77%

77%
76%

76%

74%

74%
74%

74%

73%

73%

72%
72%

71%

10%
2%

7%

1%
3%

4%
3%

4%

4%

6%

0%

11%
1%

4%

3%
0%

0%

0%

2%

0%
1%

9%

2%
1%

1%
0%

0%

6%

3%

9%

13%

5%

3%

7%

6%

3%
4%

5%

19%
0%

23%
0%

4%

Table 1: The most common signs in our EDS with 853 Patients having a frequency above 70% (34 out of 79 signs).

Citation: Hamonet C., et al. “Ehlers-Danlos Syndrome (EDS) - Contribution to Clinical Diagnosis - A Prospective Study of 853 Patients”. EC
Neurology 10.6 (2018): 428-439.