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www.elsevier.com/locate/talanta Multiplex and accurate quantiﬁcation of acute kidney injury biomarker candidates in urine using Protein Standard Absolute Quantiﬁcation (PSAQ) and targeted proteomics MARK Benoît Gilquina,b,c, Mathilde Louwagiea,b,c, Michel Jaquinoda,b,c, Alexandre Cezd, Guillaume Picarda,b,c, Leila El Kholya,b,c, Brigitte Surine, Jérôme Garina,b,c, Myriam Ferroa,b,c, Thomas Kofmanf, Caroline Baraug, Emmanuelle Plaisierd,e,h, Pierre Roncod,e,h, ⁎ Virginie Bruna,b,c, a Université Grenoble-Alpes, F-38000 Grenoble, France CEA, BIG, Biologie à Grande Echelle, F-38054 Grenoble, France INSERM, U1038, F-38054 Grenoble, France d AP-HP, Hôpital Tenon, Department of Nephrology and Dialysis, F-75020 Paris, France e INSERM, UMR_S 1155, F-75005 Paris, France f AP-HP, Hôpital Henri Mondor, Department of Nephrology, F-94010 Créteil, France g AP-HP, Hôpital Henri Mondor, Plateforme de Ressources Biologiques, F-94010 Créteil, France h Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1155, F-75005 Paris, France b c A R T I C L E I N F O A BS T RAC T Keywords:
Procalcitonin biomarker kinetics fails to predict treatment response in perioperative abdominal infection with septic shock Critical Care 2013, 17:R255 doi:10.1186/cc13082 Boris Jung (email@example.com) Nicolas Molinari (firstname.lastname@example.org) Mourad Nasri (email@example.com) Zied Hajjej (firstname.lastname@example.org) Gerald Chanques (email@example.com) Helene Jean-Pierre (firstname.lastname@example.org) Fabrizio Panaro (email@example.com) Samir Jaber (firstname.lastname@example.org) ISSN Article type 1364-8535 Research Submission date 12 June 2013 Acceptance date 11 September 2013 Publication date 24 October 2013 Article URL http://ccforum.com/content/17/5/R255 This peer-reviewed article can be downloaded, printed and distributed freely for any purposes (see copyright notice below).
Anesthesiology 2009;111:250-7 Studies (randomized clinical trials or registries) of patients undergoing CABG surgery in which postprocedural biomarker and mortality data were collected and included:
It is, therefore, a well-accepted biomarker for neuroinflammation, which can be measured in vivo using non-invasive imaging technique such as positron emission tomography (PET).
Combinations of various biomarker-based tests and imaging techniques have been evaluated for their ability to detect endometriosis.
http://www.nature.com/tp/journal/v5/n7/full/tp201591a.html Sources Chan MK, Krebs MO, Cox D, Guest PC, Yolken RH, Rahmoune H, Rothermundt M, Steiner J, Leweke FM, van Beveren NJM, Niebuhr DW, Weber NS, Cowan DN, Suarez-Pinilla P, Crespo-Facorro B, Mam-Lam-Fook C, Bourgin J, Wenstrup RJ, Kaldate RR, Cooper JD, Bahn S (2015) Development of a blood-based molecular biomarker test for identification of schizophrenia prior to disease onset, Translational psychiatry.
Results from two clinical trials of biomarker-guided therapeutic drugs that boosted immunity showed promising ﬁndings in sepsis.
Biomarker testing should be incorporated in clinical and research assessments.
There are suggestions that a high HR in itself is pathologic, rather than simply being a biomarker of sympathetic activation (4–9).
PAX1 and LMX1A Nodal diffuse large B-cell lymphomas Ovarian hMLH1, hMSH2 COL1A2 Medulloblastoma MGMT, p16 Colorectal Breast Possible predictive impact of EFEMP1 expression in primary breast cancer – correlation with poor disease-free and overall Sadr-Nabavi et al., 2009 survival FZD9 Acute myeloid leukaemia (AML) Silencing of the gene by hypermethylation plays a role in the evolution of myelodisplastic syndrome to AML Jiang et al., 2009 MGMT Barret’s adenocarcinoma Decrease of protein expression because of the gene hypermethylation correlated with advanced stage of the disease, lymph node invasion and tumour size Kuester et al., 2009 Rap1GAP Melanoma Gene down-regulation promotes melanoma cell proliferation, Zheng et al., 2009 survival, and migration BRCA1, p73, RARβ, hMLH1, RIZI, RUNX3, MGMT, TIMP3 and Reprimo Gastric Hypermethylation of eight primarily mentioned genes was statistically associated with a particular variant of gastric cancer – the signet-ring cell type – and aberrant hypermethylation of Reprimo was identiﬁed as a potential biomarker for early detection of gastric cancer Bernal et al., 2008 CADM1 Cervical Detection of dense CADM1 promoter methylation may contribute to the assembly of a valuable marker panel for the triage of high-risk HPV-positive women at risk of ≥ CIN3 Overmeer et al., 2008 Squamous cell lung The genes showed highly signiﬁcant hypermethylation in tumour tissue in comparison with adjacent non-tumour lung;
#A55 − HMGB1 as a Biomarker of Inhaled Corticosteroid Treatment Response in Moderate-Severe Asthmatic Children:
Keywords bacteremia, biomarker, fever, meningitis, serious bacterial infection, urinalysis, urinary tract infection INTRODUCTION Fever is the most common reason for emergency department (ED) visits by pediatric patients.
Monitoring the topography of emotion-triggered bodily sensations brings forth a unique tool for emotion research and could even provide a biomarker for emotional disorders.
In these types of placebo-controlled studies, culture- and biomarker-based end points may be less appropriate, since they are likely to be biased in favor of the group receiving the study drug.
Olfaction, an ancestral chemical system, is a strong candidate biomarker because it is linked to diverse physiological processes.
Once you start focusing on a target with a specific biomarker, this type of demand becomes difficult to manage, in which case you have to develop more subtle strategies,” Cosmétique 19/02/15 12:26 Feature / Enquête 073 PARTNERS eldorado ?
Because the majority of atopic dermatitis occurs in children during critical developmental periods, noninvasive biomarker capture would be ideal.
Table 3 Changes in metabolic and inﬂammatory biomarker outcomes in mindfulness and standard group.
However, the effectiveness of reducing SFA intakes in lowering the risk of CHD [4–6] has been called into question by weaknesses in the data [7, 8], the complexity of CHD , multiplicity of risk factors for the disease (e.g., genetics, smoking, age, sex, obesity, diabetes, hypertension, hyperlipidemia, physical inactivity, etc.), the inadequacy of a single biomarker to assess disease risk , certain reports and several systemic reviews [11, 12] that some SFA do not raise cholesterol levels .
The value of FIBTEM A5 as a biomarker of PPH progression was conﬁrmed in a prospective study including 356 women with PPH:
Recent studies across several laboratories showed that salivary oxytocin measured by immunoassay is a reliable biomarker, stable over time, and correlates with oxytocin-related processes like breastfeeding.
These results suggest a potential neurocognitive biomarker for persistent antisocial behavior.