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annexe dexplication de la rsl   Explicative Annex attached to RSL       Version J   January 2016           ​ TOX ALL WRK 003 - Explicative Annex attached to RSL Version J - 1st January 2016 ANNEX:  DETAILED EXPLANATIONS ON SUBSTANCES    ACCELERATORS  ALKYLPHENOLS  BIOCIDES DIMETHYL FUMARATE  POLYCHLOROPHENOLS  PESTICIDES  DYES AZO DYES  ALLERGEN DYES  BLUE COLORANT  PARAPHENYLENE DIAMINE (PPD)  FLAME RETARDANTS  SHORT CHAIN CHLORINATED PARAFFINS (SCCP)  BROMINATED & CHLORINATED FLAME RETARDANTS  CHLORINATED ORGANOPHOSPHOROUS  POLYCHLOROBIPHENYLS & POLYCHLOROTRIPHENYLS  FOAMS (chemicals found in)  AZODICARBONAMIDE  FORMAMIDE  OZONE DEPLETER GASES  ACETOPHENONE AZINE  DICUMYL PEROXYDE (DCP​ )  DINITROTOLUENE  HEAVY METALS  ANTIMONY TRIOXYDE (Sb2O3)  ARSENIC (As)  BORON (B) COMPOUNDS  CADMIUM (Cd)  CHROMIUM VI (CrVI)  COBALT (Co)  LEAD (Pb)  MERCURY (Hg)  NICKEL (Ni)  MONOMERS  ISOCYANATES  BISPHENOL A (BPA)  PHENOL  NITROSAMINES  ORGANO TIN COMPOUNDS  OTHER  BHT (Butylated Hydroxy Toluene​ )  FORMALDEHYDE  DROMETRIZOLE  HYDRAZINE  ISOCYANURATE TRIGLYCIDYLE TGIC  POLYCYCLIC AROMATIC HYDROCARBONS  PERFLUOROCARBONS (PFCs)  PHTHALATES  SOLVENTS GLYCOL ETHERS  CHLORINATED SOLVENTS  CHLORINATED BENZENES AND TOLUENES  VOLATILE ORGANIC SOLVENTS  N­METHYL­2­PYRROLIDONE  BENZYL BENZOATE  2  3  4  8  13  17  21  32  34  35  37  41  43  44  47  1/51            ​ TOX ALL WRK 003 - Explicative Annex attached to RSL Version J - 1st January 2016 ACCELERATORS    General information  Accelerators  are  used  during  the  synthesis of  the  rubber,  to  increase  the rate  & decrease  the time of the vulcanisation step.    Toxicology  All  the  ones  listed  below  are  sensitizers,  most  of  them  are  also  toxic  for  the  environment  and some of them are toxic for the reproduction.    Substances  Family  Substance  CAS  Method  Benzothiazoles (BZT1)  1,3-Benzothiazole  2-mercaptobenzothiazole (MBT)  2,2-dithiobenzothiazole (MBTS)  95-16-9   149-30-4  120-78-5  DS0836-01  Dithiocarbamates  (DTC1)  zinc dimethyldithiocarbamate (ZDMC)  zinc diethyldithiocarbamate (ZDEC)  137-30-4  14324-55-1  DS0836-04  Imidazolidine-2-thione  96-45-7  To be  defined  Sulfenamides (SULF1)  N-cyclohexylbenzothiazole-2-sulfenamide (CBS)  N-tert-butylbenzothiazole-2-sulphenamide (TBBS)   2-(morpholinothio)benzothiazole (MBS)  N,N-dicyclohexylbenzothiazole-2-sulphenamide (DCBS)  95-33-0  95-31-8  102-77-2  4979-32-2  DS0836-02  Thiurams (THIU1)   tetramethylthiuram monosulphide (TMTM)   tetramethylthiuram disulphide (TMTD)  97-74-5  137-26-8  DS0836-03  Ethylene Thiourea (ETU1)    Regulation  None of those substances are currently regulated.    Decathlon requirements  Decathlon  does  not  allow  the  presences of those  substances in skin contact component in  rubber, foam and neoprene above 1000 ppm.    Test Method  DS0836, Solvent extraction , GC-MS screening      2/51            ​ TOX ALL WRK 003 - Explicative Annex attached to RSL Version J - 1st January 2016 ALKYLPHENOLS    General Information  Nonyphenols  (NPs)  are  a  family  of compounds made of a phenol ring linked to a  straight or  branched  nonyl  goup  (chain  of  nine  carbon  atoms).  Their  general  formula  is  C6H4(OH)C9H19.  NPs  are  subjected  to  ethoxylation (addition  of  ethoxy  groups  –CH2-CH2-0-  on  the  alcohol  group)  to  give  Nonyphenol  ethoxylates  (NPEOs),  whose  general  formula  is  (C2H4O)nC15H24O.  NPEOs   belong  to  the  larger  group  of  compounds  known  as  APEOs:  alkylphenol ethoxylates.  Other  dangerous  APEOs  are   the  octylphenols  ethoxylates  (OPEOs)  which  have  same  characteristics  as  the  NPEOs.  NPEOs  are  a  group  of  man-made  chemicals  (not  naturally  present  in  the  environment).  They  are  most  widely  used  as  industrial  detergents,  wetting  agents, emulsifiers, foaming agents, and dispersants.   N.B:  ​ Currently,  in  Europe  for  most  of  their  former   uses  NPEOs  have  now  been  replaced by fatty alcohol ethoxylates, which are safer.    Toxicology  NPEOs  are  easily  degradable  in  the  environment,  its  breakdown  product  being  NPs.

Hygiène Industrielles - Respect de l'Environnement RAPPORT ANALYTIQUE CLIENT:_30034_ 150812_CABT-34 (Page 3) Liste complète des contaminants chimiques organiques toxiques dans l'air atmosphérique du site LAFARGE (mesures 29/07/2015-12/08/2015) benzene, methyl- CAS108883 dibenzothiophene, 1-ethyl- CAS89816977 R1(100) R2(200) R3(400) R5(100) R6(1100) R7(1000) benzene, 1,2,3-trimethyl- CAS526738 dibenzothiophene, 2-ethyl- CAS89816988 R1(100) R5(2500) R6(1000) benzene, 1,2,4-trimethyl- CAS95636 dibenzothiophene, 3-ethyl- CAS89817038 R1(100) R5(900) R6(100) R7(1000) benzene, 1,3,5-trimethyl- CAS108678 dibenzothiophene, 4-ethyl- CAS89816999 R1(100) R6(400) R8(400) benzene, 1,2-dimethyl- CAS95476 dodecanoic acid CAS143077 R1(100) R2(100) R3(250) R6(750) benzene, 1,3-dimethyl- CAS108383 4H-benzo[5,6]cyclohepta[1,2-b]furan, 5,10-dihydro-6,7-dimethyl- CAS56881471 R2(200) R3(250) R6(900) benzene, 1,4-dimethyl- CAS106423 chromolaenin CAS62502107 R1(100) R2(200) R3(250) R6(900) ethene, tetrachloro- CAS127184 benzene, octadecyl- CAS4445072 R3 (200) R7(850) benzene, ethyl- CAS100414 methanone, (4-chlorophenyl)(2,4-dichlorophenyl)-_CAS33146575 R1(100) R2(200) R3(350) R7(250) butane, 2-chloro-2-methyl- CAS594365 dibenzothiophene, 1-hydroxymethyl-7-methyl- CAS89816682 R1(150) R7(500) 1-butene, 2-(chloromethyl)- CAS23010028 nonadecane CAS629925 R1(400) R8(600) cyclopentane, 1,3-bis(methylene)- CAS59219486 formaldehyde CAS50000 R1(100) R1(1800) R4(3500) pyrrolidine, 2-hexyl-1-methyl- CAS3447050 .beta.-carboline, 6-methoxy-2-methyl- CAS R1(200) R5(150) cyclohexanone CAS108941 pallescensin E CAS56881471 R1(350) R5(150) cyclopentanone, 3-methyl- CAS1757422 1st peak in Fyrol polychlorinated flame retardant CAS0 R1(350) R4(300) .alpha.-pinene CAS80568 octadecane CAS593453 R1(100) R2(200) R3(500) R6(800) R8(1200) butyl glycol acetate CAS112072 s-indacene-1,7-dione, 2,3,5,6-tetrahydro-3,3,5,5-tetramethyl-CAS55591178 R1(300) R3(300) dodecane CAS112403 1,2-benzenedicarboxylic acid, dicyclohexyl ester CAS84617 R1(250) R3(60) tetradecane CAS629594 cyclopentasiloxane, decamethyl- CAS541026 R1(350) R7(800) R5(3000) R6(2000) R7(1000) R8(3700) nonanoic acid CAS112050 phthalic acid, butyl ester, with butyl glycolate CAS85701 R1(400) R3(70) octadecane, 1-(ethenyloxy)- CAS930029 benz[c]acridine, 5-methyl- CAS3519877 R1(100) R3(350) pentadecane CAS629629 hexadecanoic acid CAS57103 R1(300) R3(400) R6(1100) hexadecane CAS544763 hexadecanoic acid, 1-methylethyl ester CAS142916 R1(100) R4(200) R5(450) R1(500) R3(600) R5(1900) R6(2000) R7(1000) butyric acid, thio-, S-pentyl esterCAS2432533 sulfurous acid, diethyl ester CAS623814 R4(500) R3(100) butyric acid, thio-, S-hexyl ester CAS2432544 1,2-benzenedicarboxylic acid, butyl 2-methylpropyl ester CAS17851535 R2(200) R4(100) butyric acid, thio-, S-decyl ester CAS2432555 1,2-benzenedicarboxylic acid, bis(2-methoxyethyl) ester CAS117828 R1(200) R5(200) R6(500) R7(1000) R7(1000) 1,2-benzenedicarboxylic acid, dipropyl ester CAS131168 1,2-benzenedicarboxylic acid, dipropyl ester CAS131168 R1(100) R5(300) propanoic acid, 2-methyl-, 1-(1,1-dimethylethyl)-2-methyl-1,3-propanediyl ester CAS74381401 1,2-benzenedicarboxylic acid, bis(2-ethylhexyl) ester CAS117817 R1(300) R1(100) R7(1200) 1,2-benzenedicarboxylic acid, diethyl ester CAS84662 1,2-benzenedicarboxylic acid, butyl octyl ester CAS84786 R1(200) R7(1200) R1(100) R8(800) 1,2-benzenedicarboxylic acid, bis(2-methylpropyl) ester CAS84695 1,2-benzenedicarboxylic acid, isodecyl octyl ester CAS1330967 R1(100) R2(200) R4(800) R8(500) 1,2-benzenedicarboxylic acid, dibutyl ester CAS84742 R1(200) R2(200) R3(35) Contaminant CMR=cancérigène, mutagène, neurotoxique Contaminant PE=perturbateur endocrinien Contaminant HAP= hydrocarbure aromatique polycyclique soufré substitué Rx=n° point de prélèvement (xxx)=teneur (µg/m3) Centre Indépendant d'Investigations et d'Expertises en Chimie Organique ZAC Bousquets -130 Rue Innovation / 19 Rue Création 83390 CUERS France Tel:

4,6 dimethyl 3 ethyl 5 propyl nonane C’est la famille des alcènes, ils possèdent une seule liaison double.

EC 270-325-2 CHLORURE DE N-ALKYL(C12-16)-N,N-DIMETHYL-N-BENZYLAMMONIUM Etiquetage additionnel :

benzene, 1,2-dimethyl- CAS95476 ; benzene, 1,3-dimethyl- CAS108383 ;

Mélange Nom Identificateur de produit % Classification selon la directive 67/548/CEE 2,6-Dimethyl-octyl-7-en-2-ol # (n° CAS) 18479-58-8 (Numéro CE) 242-362-4 (N° REACH) 01-2119457274-37-XXXX 4,1 Xi;

10% Fragrance compounds Ingredient name Tetrahydro-2-isobutyl4-methylpyran-4-ol, mixed isomers (cis and trans) Linalool 3,7-dimethylona-1,6dien-3-ol 1,5-dimethyl-1vinylhept-4-enyl acetate Tetrahydro-2-isobutyl4-methylpyran-4-ol mixed isomers (cis and trans) 1-(1,2,3,4,5,6,7,8octahydro-2,,8,8tetramethyl-2-naphtyl) ethan-1-one Identifiers REACH #:

i Abbreviations 3-NT ADH Ang II Arg ALR2 ALS BAEC BCA BH4 BKCa BSA CaM CBS cGMP CSE Cys CysNO DAF-2 DA DAN deoxyHb DMSO DTNB DTPA DTT EDRF EDTA EPR ESI EtOH FAD FMN FPLC Grx GSH GSNO GSSG Hb HbNO HbSNO 3-Nitrotyrosine Alcohol dehydrogenase Angiotensin II L-Arginine Aldose reductase (aldehyde reductase 2) Amyotrophic lateral sclerosis Bovine aortic endothelial cells Bicinchoninic acid Tetrahydrobiopterin Big-conductance Ca2 -activated K channel Bovine serum albumin Calmodulin Cystathionine β-synthase Cyclic guanosine monophosphate Cystathionine γ-lyase L-Cysteine L-S -Nitrosocysteine (SNOC) DAF-2 diacetate, 4,5-diaminofluorescein diacetate 2,3-Diaminonaphthalene Deoxyhemoglobin (unliganded ferrous Hb) Dimethyl sulphoxide 5,5’-Dithio-bis(2-nitrobenzoic acid), Ellman’s reagent Diethylenetriaminepentaacetic acid Dithiothreitol Endothelium derived relaxing factor (• NO) Ethylenediamine tetraacetic acid Electron paramagnetic resonance spectroscopy Electrospray ionisation Ethanol Flavin adenine dinucleotide Flavin mononucleotide Fast protein liquid chromatography Glutaredoxin Glutathione, reduced S -Nitrosoglutathione Glutathione, oxidized Hemoglobin Nitrosylhemoglobin S -Nitrosohemoglobin ii Abbreviations HO HPLC HUVEC IC50 IRP-1 LC/MS LMW L-NAME Mb metHb mtNOS NAT NOHA NOS NOS-1 NOS-2 NOS-3 NOX oxyHb PG PGHS-2 PGI2 PN ppm PTP RLU RNS ROS SD sGC SIN-1 SMC SNAP SNP SOD SOD1 SOD2 SOD3 TCA TLC Trx Tx VEGF VSMC w/o XO YC-1 Heme oxygenase High pressure liquid chromatography Human vascular endothelial cells Half-maximal inhibition concentration Iron regulatory protein-1 Liquid chromatography/mass spectroscopy Low-molecular-weight N ω -Nitro-L-arginine methyl ester Myoglobin Methemoglobin (ferric Hb) Mitochondrial NOS 2,3-Naphthotriazole N ω -Hydroxy-L-arginine Nitric oxide synthase Neuronal NOS (nNOS) Inducible NOS (iNOS) Endothelial NOS (eNOS) NADPH oxidase Oxyhemoglobin (oxygenated ferrous Hb) Prostaglandin Prostaglandin H synthase-2 Prostacyclin Peroxynitrite parts per million Permeability transition pore Relative light unit Reactive nitrogen species Reactive oxygen species Standard deviation Soluble guanylate cyclase 3-Morpholino-sydnonimine Smooth muscle cells N -(Acetyloxy)-3-nitrosothiovaline Sodium nitroprusside Superoxide dismutase Cu,Zn-SOD, cytosolic Mn-SOD, mitochondrial EC-SOD, extracellular Cu,Zn-SOD Tricarboxylic acid Thin-layer chromatography Thioredoxin Thromboxane Vascular endothelial growth factor Vascular smooth muscle cells without Xanthine oxidase 1-Benzyl-3-(5-hydroxymethyl-2-furyl)indazole iii Publications Results from this work were published in the following articles:

hydroxyde de potassium (40%), alpha-naphtol (6%), acide sulfanilique (0,8%), NN-dimethyl-alpha-naphtylamine (0,05%), chlorure ferrique (10%), réactif de Kovac ou James, poudre de zinc • Méthode :

N -cyclohexyl-N -methoxy-2,5-dimethyl-3-furamide 60568-05-0 Carc.

After microscopic examination (Leitz Laborlux K), pieces were glued on a rectangular card in a drop of water-soluble resin (dimethyl hydantoin formaldehyde).

Cocamide DEA, Lauramide DEA, Cocamide MEA, Cocamide MIPA, Lauramide MEA, Soyamine DEA, Acetamide MEA, Cocamidopropyl Betainamide MEA Chloride, Dimethyl Mea, Disodium Ricinoleamido MEA-Sulfosuccinate, Trideceth-2 Carboxamide MEA, TEA Cocoate, TEA Cocoyl Glutamate, TEA Lactate, TEA Lauryl Sulfate, TEA-Carbomer, TEA-Dodecylbenzenesulfonate, TEA-Palmitate, TEA-Stearate, TEA-Sulfate, tout ce qui contient dans son nom DEA, MEA, TEA ou MIPA.

Raspet has altered the original structure of 7-hydroxycitronellal by substituting a sila-dimethyl group at the position of the 4th carbon of the original molecule (Figure 3).

La défériprone (1,2-dimethyl-3-hydroxypyridin-4-one, Ferriprox®) est une molécule qui remplit l’ensemble de ces critères.

200-659-6 DIMYRCETOL (2,6-DIMETHYL-7-OCTEN-2-OL) INDEX:

01-2119484688-17 CHLORURE D'ALKYL DIMETHYL HYDROXYETHYL AMMONIUM CAS:

01-2119484688-17 CHLORURE D'ALKYL DIMETHYL HYDROXYETHYL AMMONIUM CAS:

le N,N-Bis-(2-hydroxyéthyl)-N’,N’-dimethyl-urée ;

Supramolecular Ru−Re complexes with a Ru trisdiimine moiety linked to a Re(I)(diimine)(CO)2X2 (X = P(p-C6H4F)3) catalyst are remarkable examples of this approach, and current results have shown that by using the more powerful electron donor 1,3-dimethyl-2phenyl-2,3-dihydro-1H-benzo[d]imidazole (BIH) instead of the more common 1-benzyl-1,4-dihydronicotinamide, the efficiency, durability, and reaction rate are improved significantly (ΦCO = 0.45, TONCO = 3029, and TOFCO = 35.5 min−1).42 However, we are still far from a practical system that overcomes numerous limitations including:

28 (6) Risk factors and comorbidities Diabetes mellitus Hypertension Cardiac status Serum creatinine concentration, μM New York Heart Association class 80 (71–96) 80 (71–99) 2·2 (0·6) 2·2 (0·6) 0·78 0·96 Left ventricular mass index, g/m2.7 49 (15) 50 (16) 0·36 Left ventricular ejection fraction, % 62% (8) 62% (8) 0·67 Left main artery ≥50% stenosis 48 (16%) 51 (17%) 0·83 Three-vessel coronary artery disease 46 (15%) 42 (14%) 0·73 Euroscore II, % 1·78% (1·32) STS morbidity risk, % 12·1% (6·5) 1·76% (1·32) 0·87 12·1% (6·6) 0·99 Preoperative medication Aspirin 77 (26%) 72 (24%) 0·50 Beta blockers 74 (25%) 68 (23%) 0·42 164 (55%) 160 (54%) 0·74 Angiotensin-converting enzyme inhibitors or angiotensin receptor blockers Statins 125 (42%) 131 (44%) 0·62 Diuretics 134 (45%) 133 (44%) 0·93 Cardiopulmonary bypass duration, min 93 (32) 92 (31) 0·83 Aortic cross-clamp duration, min 74 (30) 74 (27) 0·90 Concomitant coronary artery bypass graft 81 (27%) 70 (24%) 0·40 Surgery characteristics Number of coronary artery bypass graft anastomoses Biological prosthesis hearts after in-vivo administration (25 mg/kg [or dimethyl sulfoxide vehicle] given intraperitoneally at ZT8 and ZT11).