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Immuno-Antigènes-2009 100%

Brandouy Laura Yasmine Abdelhamid LES ANTIGENES Plan DEFINTIONS GENERALITES -Immunité innée -Immunité adptative LES ANTIGENES -Définitions -Epitope -SuperAntigène -Structure -Aspects fonctionnels INTERACTION ENTRE EPITOPES ET PARATOPES 1/12 LES ANTIGENES I Définitions Immunité :


s41586 020 2550 z reference 92%

Table 1 summarizes the different T cell epitopes defined by both ELISpot and ICS, in 7 COVID-19 recovered individuals.


P2-Immunologie-Antigènes-1909 91%

Tous les Ag globalement sont différents, néanmoins on peut avoir des épitopes présents sur 2 antigènes différents.


CBP . Lancet 2011 64%

they are detected in nearly 95% of patients, with specificity close to 100% when tested with recombinant antigens.41 Indirect immunofluorescence remains the test used for screening, but it can be associated with a substantial number of falsepositive results.49 Follow-up data from AMA-positive individuals without signs of liver disease suggest that autoantibodies arise several years before onset of primary biliary cirrhosis and have a high predictive value.50 Epitopes recognised by AMAs include lipoylated domains (via the Asx-Lys-Ala motif) within subunits of the 2-oxoacid dehydrogenase family of enzymes of the mitochondrial respiratory chain,6 in particular, E2 subunit and E3 binding-protein components of the pyruvate dehydrogenase complex and E2 components of the 2-oxoglutarate dehydrogenase and branched-chain 2-oxo acid dehydrogenase complexes (table).51,52 In addition to AMAs, autoreactive CD8+ and CD4+ T cells to the E2 component of the pyruvate dehydrogenase complex have been identified both in peripheral blood and within the liver of patients with primary biliary cirrhosis, and the immunodominant epitope of these T cells maps in close proximity to the epitope recognised by AMAs in serum.


أنواع الـمناعـــة Types of Immunity 60%

CELL-MEDIATED IMMUNITY‬‬ ‫ﻓﻲ ﻫﺫﺍ ﺍﻟﻤﺜﺎل ﻴﺩﺨل ﺍﻟﺒﻜﺘﻴﺭﻴﺎ ﻟﻠﺠﺴﻡ ﺤﻴﺙ ﺘﺒﺘﻠﻌﻪ ﺍﻟﺒﺎﻟﻌﺎﺕ ﺍﻟﻜﺒﻴﺭﺓ‬ ‫‪ macrophage‬ﻭﺘﺠﺯﺌﻪ؛ ﺜﻡ ﺘﻅﻬﺭ ﻗﻁﻊ ﻤﻨﻪ )ﺍﻟﻤﺴﺘﻀﺩﺍﺕ ‪، antigens‬‬ ‫ﺍﻟﺠﺴﻴﻤﺎﺕ ﺍﻟﻤﻤﺜﻠﺔ ‪ (epitopes‬ﻋﻠﻰ ﺴﻁﺢ ﺍﻟﺒﺎﻟﻌﺔ ﺍﻟﻜﺒﻴﺭﺓ ﻤﺘﺭﺍﻓﻘ ﹲﺔ ﻤﻊ ﺒﺭﻭﺘﻴﻨﺎﺕ‬ ‫ﺍﻟﺼﻑ ‪ II‬ﻤﻥ ﻤﺭﻜﺏ ﺍﻟﺘﻭﺍﻓﻕ ﺍﻟﻨﺴﺠﻲ ﺍﻟﺭﺌﻴﺱ )‪ .(MHC‬ﻴﺘﻔﺎﻋل ﻤﺭﻜﺏ ﺍﻟﻤﺴﺘﻀﺩ‬ ‫– ﺒﺭﻭﺘﻴﻥ ﺍﻟﺼﻑ ‪ II‬ﻤﻊ ﺍﻟﻤﺴﺘﻘﺒﻼﺕ ﺍﻟﻨﻭﻋﻴﺔ ﻟﻠﻤﺴﺘﻀﺩﺍﺕ ﻭﺍﻟﻤﻭﺠﻭﺩﺓ ﻋﻠﻰ ﺴﻁﺢ‬ ‫ﺍﻟﻠﻤﻔﺎﻭﻴﺔ ‪ T‬ﺍﻟﻤﺴﺎﻋﺩﺓ‪ ،‬ﻭﻴﺤﺩﺙ ﻟﻬﺫﻩ ﺍﻟﺨﻼﻴﺎ ‪ T‬ﺍﻟﻤﺴﺎﻋﺩﺓ ﺍﻟﻨﻭﻋﻴﺔ ﻟﻠﻤﺴﺘﻀﺩ ﺘﻔﻌﻴل‬ ‫ﻭﺘﻜﺎﺜﺭ ﻨﺴﻠﻲ‬ ‫‪ clonal proliferation‬ﺍﺴﺘﺠﺎﺒﺔ ﻻﻨﺘﺎﺝ ﺍﻟﻠﻤﻔﻭﻜﻴﻨﺎﺕ‬ ‫‪ lymphokines‬ﻭﺃﻫﻤﻬﺎ ﺍﻻﻨﺘﺭﻟﻭﻜﻴﻥ ‪) ١‬ﺍﻟﺫﻱ ﺘﻨﺘﺠﻪ ﺍﻟﺒﺎﻟﻌﺎﺕ ﺍﻟﻜﺒﻴﺭﺓ(‬ ‫ﻭﺍﻻﻨﺘﺭﻟﻭﻜﻴﻥ ‪) ٢‬ﺍﻟﺫﻱ ﺘﻨﺘﺠﻪ ﺍﻟﻠﻤﻔﺎﻭﻴﺎﺕ(‪ .‬ﻭﺍﻟﺨﻼﻴﺎ ‪ T‬ﺍﻟﺘﻲ ﺘﻔﻌﻠﺕ ﺘﺘﻭﺍﺴﻁ ﺃﺤﺩ‬ ‫ﺍﻟﻤﻜﻭﻨﺎﺕ ﺍﻟﻬﺎﻤﺔ ﻟﻠﻤﻨﺎﻋﺔ ﺍﻟﺨﻠﻭﻴﺔ ﺃﻱ ﺍﺭﺘﻜﺎﺱ ﻓﺭﻁ ﺍﻟﺤﺴﺎﺴﻴﺔ ﺍﻟﻤﺘﺄﺨﺭ ﻀﺩ ﺍﻟﺒﻜﺘﻴﺭﻴﺎ‪.‬‬ ‫ﺘﺘﻭﺍﺴﻁ ﺍﻟﻠﻤﻔﺎﻭﻴﺎﺕ ‪ T‬ﺍﻟﺴﺎﻤﺔ ﻟﻠﺨﻼﻴﺎ ‪cytotoxic T lymphocytes‬‬ ‫ﻤﻜﻭﻨﹰﺎ ﻫﺎﻤﹰﺎ ﺁﺨﺭ ﻤﻥ ﺍﻻﺴﺘﺠﺎﺒﺔ ﺍﻟﻤﻨﺎﻋﻴﺔ ﺍﻟﺨﻠﻭﻴﺔ‪ .‬ﻓﻲ ﻫﺫﺍ ﺍﻟﻤﺜﺎل ﻴﺴﺘﻨﺸﻕ ﻓﻴﺭﻭﺱ –‬ ‫ﻜﻔﻴﺭﻭﺱ ﺍﻻﻨﻔﻠﻭﻨﺯﺍ – ﻭﻴﺼﻴﺏ ﺨﻠﻴﺔ ﻓﻲ ﺍﻟﺠﻬﺎﺯ ﺍﻟﺘﻨﻔﺴﻲ‪ ،‬ﺜﻡ ﺘﻅﻬﺭ ﻏﻠﻴﻜﻭﺒﺭﻭﺘﻴﻨﺎﺕ‬ ‫ﻏﻼﻑ ﺍﻟﻔﻴﺭﻭﺱ ﻋﻠﻰ ﺴﻁﺢ ﺍﻟﺨﻠﻴﺔ ﺍﻟﻤﺼﺎﺒﺔ ﻤﺘﺭﺍﻓﻘﺔ ﻤﻊ ﺒﺭﻭﺘﻴﻨﺎﺕ ﺍﻟﺼﻑ ‪ ١‬ﻤﻥ‬ ‫‪ .MHC‬ﺘﺭﺘﺒﻁ ﺨﻠﻴﺔ ‪ T‬ﺴﺎﻤﺔ ﻟﻠﺨﻼﻴﺎ ﺒﻭﺍﺴﻁﺔ ﺍﻟﻤﺴﺘﻘﺒل ﺍﻟﻨﻭﻋﻲ ﻟﻠﻤﺴﺘﻀﺩ –‬ ‫ﺒﺭﻭﺘﻴﻥ ﺍﻟﺼﻑ ‪ ،١‬ﻭﺘﺘﺤﺭﺽ ﺒﺎﻻﻨﺭﺘﻠﻭﻜﻴﻥ ‪ ٢‬ﺍﻟﺫﻱ ﺘﻨﺘﺠﻪ ﺍﻟﺨﻼﻴﺎ ‪ T‬ﺍﻟﻤﺴﺎﻋﺩﺓ ﻟﺘﻨﻤﻭ‬ ‫ﻓﻲ ﻤﺠﻤﻭﻋﺔ ﻤﻥ ﺍﻟﺨﻼﻴﺎ ﺘﺴﺘﻁﻴﻊ ﻫﺫﻩ ﺍﻟﺨﻼﻴﺎ ‪ T‬ﺍﻟﺴﺎﻤﺔ ﻟﻠﺨﻼﻴﺎ ﺃﻥ ﺘﻘﺘل ﺒﺸﻜل‬ ‫ﺨﺎﺹ ﺍﻟﺨﻼﻴﺎ ﺍﻟﻤﺼﺎﺒﺔ ﺒﻔﻴﺭﻭﺱ ﺍﻻﻨﻔﻠﻭﻨﺯﺍ ﻭﺫﻟﻙ ﺒﺎﻟﺘﻌﺭﻑ ﻋﻠﻰ ﻤﺭﻜﺒﺎﺕ ﺍﻟﻤﺴﺘﻀﺩ‬ ‫ﺍﻟﻔﻴﺭﻭﺴﻲ – ﺒﺭﻭﺘﻴﻥ ﻟﺼﻑ ‪ I‬ﻋﻠﻰ ﺴﻁﺢ ﺍﻟﺨﻠﻴﺔ‪.‬‬ ‫ﺍﻟﺠﺩﻭل ‪ .1- 00‬ﺍﻟﻭﻅﺎﺌﻑ ﺍﻟﺭﺌﻴﺴﻴﺔ ﻟﻠﺨﻼﻴﺎ ‪ T‬ﻭﺍﻟﺨﻼﻴﺎ ‪:


Platelet production and destruction in liver cirrhosis 39%

LJ-P3 and LJ-P19 monoclonal antibodies interact with epitopes only present in the native glycoproteins located within residues 1-290.


PIIS147149220200065X 24%

(1994) Identification of Babesia bigemina infected erythrocyte surface antigens containing epitopes conserved among strains.