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3-Gresch-JNchem-1995 100%

Joutnal of Neurochemistry Raven Press, Ltd ., New York 1995 International Society for Neurochemistry Local Influence of Endogenous Norepinephrine on Extracellular Dopamine in Rat Medial Prefrontal Cortex *Paul J .



Consistent with this new concept, recent studies have reported that human tau can be released in the extracellular space by an active process of secretion, and can be endocytosed both in vitro and in vivo.


4-Carboni-JNeurosci-2001 86%

21 RC141 1 of 4 Cocaine and Amphetamine Increase Extracellular Dopamine in the Nucleus Accumbens of Mice Lacking the Dopamine Transporter Gene Ezio Carboni,1 Ce´cile Spielewoy,2 Cinzia Vacca,1 Marika Nosten-Bertrand,2 Bruno Giros,2 and Gaetano Di Chiara1 Department of Toxicology and Consiglio Nazionale delle Ricerche Center for Neuropharmacology, University of Cagliari, 09126 Cagliari, Italy, and 2Neurobiology and Psychiatry Faculte´ de Medicine de Creteil, 94000 Creteil, France 1 Behavioral and biochemical studies suggest that dopamine (DA) plays a role in the reinforcing and addictive properties of drugs of abuse.


2-Rocha-Nat1998 86%

Cocaine blockade of DAT leads to increased extracellular dopamine, an effect widely considered to be the primary cause of the reinforcing and addictive properties of cocaine.


1 82%

Protein patterning was one of the first techniques used for guidance with defined geometries and patterns on a substrate using microcontact printing25,26 or with lithography methods.27 In these cases, the patterned protein is recognized by the receptors of the cells that are responsible for the cell−extracellular matrix boundary.28,29 The major limitation of these techniques is that the protein pattern is restricted to two dimensions, since the thickness of the protein layer is negligible compared with the ultielectrode arrays (MEAs) have been largely used for characterizing cellular networks, especially for the investigation of electrical active cells.1−3 In the recent years, we continuously improved these devices regarding their interface properties and consequently allowing the extracellular recording of action potentials and electrical and optical stimulation.4−8 A crucial point for the recording of extracellular signals is the contact between the cell membrane and the active part of the device:


Matrigel 74%

The ability to identify the low mass and abundance components of Matrigel illustrates the utility of this method for the analysis of the extracellular matrix, as well as the complexity of the matrix itself.


scleroderma 63%

Scleroderma-associated polymorphisms of genes encoding cytokines, cytokine receptors, chemokines, and extracellular proteins have been reported.10 Many of these variants have been linked to cohorts of patients, but few have been independently confirmed.


14.10.15 8H00-9H00 TAGZIRT (cours 1) 61%

n°11 Remarques du professeur • Diapos sur Moodle PLAN DU COURS I) Généralités II) Morphologie III) Propriétés des PNN A) X B) X C) Réponse pro-inflammatoire IV) La phagocytose A) Reconnaissance de l'agent pathogène 1) Les récepteurs aux opsonines 2) Les récepteurs du complément 3) Les récepteurs non opsoniques B) L'internalisation V) La bactéricidie VI) La dégranulation A) Fusion des granulations azurophiles B) Fusion des vésicules avec la membrane plasmique 1) Granules primaires 2) Granules secondaires ou spécifiques 3) Granules tertiaires 4) Vésicules sécrétoires C) Fusion des granules azurophiles avec la vacuole phagocytaire 1) Rôle de la lactoferrine 1/10 2015-2016 Granulopoïèse neutrophile 2) Le Cytb558 3) La MPO D) La NADPH oxydase 1) PNN non activé 2) PNN activé 3) Mécanismes de défenses des bactéries 4) Le bacille de la tuberculose E) La myéloperoxydase F) Fusion des vésicules avec la membrane plasmique = exocytose VII) 1) Neutropils extracellular Traps 2) Production de médiateurs de l'inflammation 3) Résolution de l'épisode inflammatoire Méthodes détudes des PNN et granulopoïèse A) Exploration granulopoïèse B) Les pathologies 2/10 2015-2016 Granulopoïèse neutrophile C) réponse pro-inflammatoire Le PNN est la cellule la plus représentée parmi les leucocytes.


BIO-10 2009 60%

…To pluricellular Organisms 1 22/03/10 Advantages of multicellularity Specialization of cells More resistant to aggressors 2 22/03/10 Adaptation Needed Cell-cell adhesion Extracellular Matrix Cell-Matrix adhesion Tissues organization Cell communication •  molecular •  electric Functions to be sustain:


Postdoc eq Soler Chromatin Looping1 59%

Specifically, the regulation of enhancer-gene looping events during cellular differentiation or in response to extracellular signaling remains obscure.


postdoc 58%

PROJECT We are generally interested in understanding of how the complex environment that cells experience in vivo (neighboring cells, extracellular matrix, chemical cues, mechanical constraints) influences their migration, and how it allows coordination of cell behavior, ensuring proper morphogenesis and development.


postdoctoral position 58%

The project will involve further studies of the role of DORN1 in reception of extracellular ATP and downstream signaling, as well as characterization of various Arabidopsis mutants defective in purinergic signaling.


Neurophotonic 51%

mechanisms and functions Live-cell imaging of synapses at nanoscopic resolution by STED microscopy Wine and cheese party Tuesday 21st Session 3 (Chair Paul De Koninck) 9:00 9:40 9:40 - 10:20 David Kleinfeld Dmitri Rusakov Topology and Control in Cortical Blood Flow Revealed with Linear and Nonlinear Optical Methods Nano-diffusion in the brain extracellular space examined with time-resolved fluorescence anisotropy imaging (TR-FAIM) Session 4 10:20 - 11:00 11:00 - 11:30 11:30 - 12:10 Richard Tsien 12:10 - 12:50 Maxime Dahan 12:50 - 14:20 (Chair Ehud Isacoff) 14:20 - 15:00 15:00 - Arthur Konnerth In vivo two-photon imaging of mouse visual cortex signaling at eye-opening pause Tracking the dynamics of single vesicles with Qdots and other optical probes Investigating cell dynamics at the single molecule level using quantum dots lunch Gaudanz Danuser 15:40 Petra Schwille High-content image analysis in early steps of endocytosis Fluorescence Correlation Spectroscopy in live cells and reconstituted systems Talks selected from abstracts 15:40 - 16:00 Philipp Schoenenberger 16:00 - 16:20 Pierre Marquet 16:20 - 16:50 16:50 - 17:30 Paul Wiseman 17:30 - 18:10 Ryuichi Shigemoto Optimizing the spatial resolution of Channelrhodopsin-2 activation Living cell analysis with Digital Holographic microscopy pause Advances in image correlation methods for measurements in live cells and neurons Correlative study of central synapses by fluorescence and electron microscopy winecellar visit bus at 18h30 Gala dinner at chateau Bouscaut Bus return around 23h30 Wenesday 22nd Session 5 (Chair Richard Tsien) 9:00 - 9:40 Ehud Isacoff Light-gated ion channels 9:40 - 10:20 Jerome Mertz 10:20 - 11:00 Karl Deisselroth New approaches towards fluorescence background rejection Optogenetics:


topiramateCocaine 51%

An intact GABA efferent system from the nucleus accumbens, corpus striatum, and ventral pallidum to cortical structures6,7 is important for the expression of cocaine reinforcement.8 Excitatory amino acids, including glutamate, are associated with the acquisition of place preference conditioning and other reinforcing effects of cocaine.9-11 Furthermore, the enhancement of GABA pathways or the inhibition of corticofugal glutaminergic pathways in the mesocorticolimbic dopamine system can decrease extracellular dopamine release,12,13 the principal neurotransmitter that mediates cocaine reinforcement.


Proposition stage M2 2017 2018 sujet Slayers 51%

Isolation and characterization of environmental bacteria with mercury extracellular biosorption capacities, Applied and Environmental Microbiolology, 78:


7-Spielewoy-Psychopharm 2001 49%

Mice lacking the dopamine transporter (DAT–/–) exhibit high extracellular dopamine levels and marked hyperactivity.


AqualacVol5N2- Characerization of hardness 48%

In extracellular level, magnesium is required to maintain the efflux of calcium from the endoplasmic reticulum and comes into competition at the sites of calciproteins (troponine C,…, calmoduline) which participate in the contractile mechanism (Berthelot, 2003).


8-Mead-EJN 2002 48%

(2001) reported that both cocaine and amphetamine increase extracellular levels of dopamine (DA) in the nucleus accumbens (NAcc) of DAT-KO mice.


Dissertation D Frein 48%

i Abbreviations 3-NT ADH Ang II Arg ALR2 ALS BAEC BCA BH4 BKCa BSA CaM CBS cGMP CSE Cys CysNO DAF-2 DA DAN deoxyHb DMSO DTNB DTPA DTT EDRF EDTA EPR ESI EtOH FAD FMN FPLC Grx GSH GSNO GSSG Hb HbNO HbSNO 3-Nitrotyrosine Alcohol dehydrogenase Angiotensin II L-Arginine Aldose reductase (aldehyde reductase 2) Amyotrophic lateral sclerosis Bovine aortic endothelial cells Bicinchoninic acid Tetrahydrobiopterin Big-conductance Ca2+ -activated K+ channel Bovine serum albumin Calmodulin Cystathionine β-synthase Cyclic guanosine monophosphate Cystathionine γ-lyase L-Cysteine L-S -Nitrosocysteine (SNOC) DAF-2 diacetate, 4,5-diaminofluorescein diacetate 2,3-Diaminonaphthalene Deoxyhemoglobin (unliganded ferrous Hb) Dimethyl sulphoxide 5,5’-Dithio-bis(2-nitrobenzoic acid), Ellman’s reagent Diethylenetriaminepentaacetic acid Dithiothreitol Endothelium derived relaxing factor (• NO) Ethylenediamine tetraacetic acid Electron paramagnetic resonance spectroscopy Electrospray ionisation Ethanol Flavin adenine dinucleotide Flavin mononucleotide Fast protein liquid chromatography Glutaredoxin Glutathione, reduced S -Nitrosoglutathione Glutathione, oxidized Hemoglobin Nitrosylhemoglobin S -Nitrosohemoglobin ii Abbreviations HO HPLC HUVEC IC50 IRP-1 LC/MS LMW L-NAME Mb metHb mtNOS NAT NOHA NOS NOS-1 NOS-2 NOS-3 NOX oxyHb PG PGHS-2 PGI2 PN ppm PTP RLU RNS ROS SD sGC SIN-1 SMC SNAP SNP SOD SOD1 SOD2 SOD3 TCA TLC Trx Tx VEGF VSMC w/o XO YC-1 Heme oxygenase High pressure liquid chromatography Human vascular endothelial cells Half-maximal inhibition concentration Iron regulatory protein-1 Liquid chromatography/mass spectroscopy Low-molecular-weight N ω -Nitro-L-arginine methyl ester Myoglobin Methemoglobin (ferric Hb) Mitochondrial NOS 2,3-Naphthotriazole N ω -Hydroxy-L-arginine Nitric oxide synthase Neuronal NOS (nNOS) Inducible NOS (iNOS) Endothelial NOS (eNOS) NADPH oxidase Oxyhemoglobin (oxygenated ferrous Hb) Prostaglandin Prostaglandin H synthase-2 Prostacyclin Peroxynitrite parts per million Permeability transition pore Relative light unit Reactive nitrogen species Reactive oxygen species Standard deviation Soluble guanylate cyclase 3-Morpholino-sydnonimine Smooth muscle cells N -(Acetyloxy)-3-nitrosothiovaline Sodium nitroprusside Superoxide dismutase Cu,Zn-SOD, cytosolic Mn-SOD, mitochondrial EC-SOD, extracellular Cu,Zn-SOD Tricarboxylic acid Thin-layer chromatography Thioredoxin Thromboxane Vascular endothelial growth factor Vascular smooth muscle cells without Xanthine oxidase 1-Benzyl-3-(5-hydroxymethyl-2-furyl)indazole iii Publications Results from this work were published in the following articles:


10-Moron-JNeurosci2002 47%

This assay allows us to dissociate changes in extracellular DA that result from altered DA clearance from changes that result from altered DA release, which can be secondary to elevations in NE or 5-HT (Pozzi et al., 1994, 1999;


Ransohoff2016Science 45%

Composition of aggregate Associated disorders Physiological localization Localization in disease A-b AD, PDD Membrane Extracellular .....................................................................................................................................................................................................................


glutamic acid 45%

In inhalation anthrax, capsule expression occurs soon after macrophage engulfment and spore germination in response to host signals that include raised CO2 (Koehler, 2002), and ensures extracellular bacterial replication.


0054 45%

poor spatial resolution, since the extracellular microelectrodes typically used today simultaneously interface with all neurons within approximately 100µm;


JCRreport2019 2020 43%

Microbe 15.923 Q1 140 Advanced Science 15.840 Q1 141 MOLECULAR CELL 15.584 Q1 142 Annual Review of Biomedical Engineering 15.541 Q1 143 Nature Microbiology 15.540 Q1 144 FUNGAL DIVERSITY 15.386 Q1 145 COORDINATION CHEMISTRY REVIEWS 15.367 Q1 146 Molecular Cancer 15.302 Q1 147 TRENDS IN COGNITIVE SCIENCES 15.218 Q1 149 PROGRESS IN LIPID RESEARCH 15.083 Q1 150 Journal of Extracellular Vesicles 14.976 Q1 151 PSYCHOTHERAPY AND PSYCHOSOMATICS 14.864 Q1 153 PROGRESS IN RETINAL AND EYE RESEARCH 14.860 Q1 154 Annual Review of Condensed Matter Physics 14.833 Q1 155 Lancet HIV 14.813 Q1 156 Lancet Gastroenterology &


Raper2016TrendsNeurosci 42%

also known as extracellular link domain containing 1 (XLKD1).