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pdfjoiner 100%



restrictive-blood-transfusion-strategies-2014 99%

The MEDLINE database was searched from 1966 to April 2013 to find randomized trials evaluating a restrictive hemoglobin transfusion trigger of <7 g/dL, compared with a more liberal trigger.


Blood Transfusions in Cardiac Surgery 99%

A study of patients undergoing cardiac surgical procedures who refused blood transfusions Low preoperative hemoglobin significant independent predictor of noncardiac adverse events Minimum hematocrit significant risk factor for postoperative mortality Lowest hematocrit significantly associated with increased risk of in-hospital mortality, need for intraaortic balloon pump, and return to cardiopulmonary bypass Lowest hematocrit significantly associated with worse renal function, more myocardial injury, longer ventilator support, longer hospital stay, and increased mortality Lowest hematocrit associated with increased risk of postoperative stroke for religious reasons found a 0% mortality rate but a 9.4% morbidity rate in those with a postoperative hemoglobin of 7.1 to 8.0 g/dL (Table 2) [16].


nejmra Sickle Cell Disease 97%

Estimates suggest that every year approximately 300,000 infants are born with sickle cell anemia, which is defined as homozygosity for the sickle hemoglobin (HbS) gene (i.e., for a missense mutation [Glu6Val, rs334] in the β-globin gene [HBB]) and that this number could rise to 400,000 by 2050.1 Although early diagnosis, penicillin prophylaxis, blood transfusion, transcranial Doppler imaging, hydroxyurea, and hematopoietic stem-cell transplantation can dramatically improve survival and quality of life for patients with sickle cell disease, our understanding of the role of genetic and nongenetic factors in explaining the remarkable phenotypic diversity of this mendelian disease is still limited.


choisir avec soin anglais 74%

Five Things Physicians and Patients Should Question 1 Don’t initiate erythropoiesis-stimulating agents (ESAs) in chronic kidney disease (CKD) patients with hemoglobin levels greater than or equal to 100 g/L without symptoms of anemia.


Glycémie et Complications en chirurgie cardiaque 73%

In the setting of protocolized glycemic control, the relationship between postoperative glycemic variability on major adverse events (MAEs) after cardiac surgery is unknown for patients with increased preoperative hemoglobin A1C (HbA1C >6.5%).


Carbon Monoxide Poisoning In Children - 73%

Developing fetuses and newborn infants are more vulnerable to carbon monoxide poisoning because of the persistence of fetal hemoglobin.


30.09.15 8H00-9H00 TAGZIRT 72%

2015-2016 Physiologie du globule rouge Hématologie – UE 7:


Vit D Levels in Recurrent Respiratory Chronic cough 69%

calcium, phosphorus, hemoglobin, white blood cell count, eosinophil (%), mean platelet volume (MPV), 25(OH)D levels were measured in each case.


pros23141 66%

Eastern Cooperative Oncology Group performance status (ECOG-PS), baseline hemoglobin (g/dl), alkaline phosphate (UI/l), albumin (g/dl), PSA (ng/ml) levels, presence of pain-related symptoms ( 3 on the visual analogue pain scale) and the extent of the disease (minimal disease vs.





Prevalence of Subclinical Hypothyroidism 63%

Demographic characteristics (age, gender, diabetes mellitus, current smoking, and duration of dialysis), laboratory variables [hemoglobin, blood urea nitrogen, serum levels of creatinine, albumin, phosphorus, and calcium, alkaline phosphatase, a single determination of the albumin/creatinine ratio (ACR) in a spot urine sample, and fasting lipid profile], clinical parameters (systolic and diastolic blood pressure, and body mass index) were obtained from all study participants.


art%3A10.1007%2Fs10147-011-0275-6 63%

Levels of pre-treatment platelet count, hemoglobin, serum alkaline phosphatase (ALP), serum lactate dehydrogenase (LDH) and PSA were measured prior to initial DEC therapy, and only PSA levels were measured every 3 months thereafter.


Altered Level Of Consciousness 62% This disrupts the ability of the hemoglobin molecule to carry oxygen, which, in turn, can cause tissue hypoxemia.


Annonce postdoc ou CDD ingénieur 62%

Heme (the blood hemoglobin cofactor) is a vital but toxic molecule for nearly all organisms.


LuminoTTTAJP 60%

This model postulates that tetrapyrrole pigments, including hemoglobin and bilirubin, are blood-borne photoreceptors, regulating gasotransmitters such as carbon monoxide when exposed to light in the eye.


Residual Intestinal Disease After Milk Allergy 59%

However, all subjects had normal hemoglobin and whole-blood folic acid levels.


NMR 57%

an increased activity of a specific area is due to the consumption of a little more oxygen by neurons, largely compensated by an increased blood flow, conveying oxygenated hemoglobin (Hb).


doc17619 53%

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Peds0914 Hematuria 53%

The test utilizes the peroxidase activity of hemoglobin to catalyze a chemical reaction that converts chromogen tetramethylbenzidine to an oxidized chromogen, which has a green-blue color.5 This testing has a reported sensitivity as high as 100% and a specificity of 99% to detect 5 Copyright © 2014 EB Medicine.


Dissertation D Frein 52%

i Abbreviations 3-NT ADH Ang II Arg ALR2 ALS BAEC BCA BH4 BKCa BSA CaM CBS cGMP CSE Cys CysNO DAF-2 DA DAN deoxyHb DMSO DTNB DTPA DTT EDRF EDTA EPR ESI EtOH FAD FMN FPLC Grx GSH GSNO GSSG Hb HbNO HbSNO 3-Nitrotyrosine Alcohol dehydrogenase Angiotensin II L-Arginine Aldose reductase (aldehyde reductase 2) Amyotrophic lateral sclerosis Bovine aortic endothelial cells Bicinchoninic acid Tetrahydrobiopterin Big-conductance Ca2+ -activated K+ channel Bovine serum albumin Calmodulin Cystathionine β-synthase Cyclic guanosine monophosphate Cystathionine γ-lyase L-Cysteine L-S -Nitrosocysteine (SNOC) DAF-2 diacetate, 4,5-diaminofluorescein diacetate 2,3-Diaminonaphthalene Deoxyhemoglobin (unliganded ferrous Hb) Dimethyl sulphoxide 5,5’-Dithio-bis(2-nitrobenzoic acid), Ellman’s reagent Diethylenetriaminepentaacetic acid Dithiothreitol Endothelium derived relaxing factor (• NO) Ethylenediamine tetraacetic acid Electron paramagnetic resonance spectroscopy Electrospray ionisation Ethanol Flavin adenine dinucleotide Flavin mononucleotide Fast protein liquid chromatography Glutaredoxin Glutathione, reduced S -Nitrosoglutathione Glutathione, oxidized Hemoglobin Nitrosylhemoglobin S -Nitrosohemoglobin ii Abbreviations HO HPLC HUVEC IC50 IRP-1 LC/MS LMW L-NAME Mb metHb mtNOS NAT NOHA NOS NOS-1 NOS-2 NOS-3 NOX oxyHb PG PGHS-2 PGI2 PN ppm PTP RLU RNS ROS SD sGC SIN-1 SMC SNAP SNP SOD SOD1 SOD2 SOD3 TCA TLC Trx Tx VEGF VSMC w/o XO YC-1 Heme oxygenase High pressure liquid chromatography Human vascular endothelial cells Half-maximal inhibition concentration Iron regulatory protein-1 Liquid chromatography/mass spectroscopy Low-molecular-weight N ω -Nitro-L-arginine methyl ester Myoglobin Methemoglobin (ferric Hb) Mitochondrial NOS 2,3-Naphthotriazole N ω -Hydroxy-L-arginine Nitric oxide synthase Neuronal NOS (nNOS) Inducible NOS (iNOS) Endothelial NOS (eNOS) NADPH oxidase Oxyhemoglobin (oxygenated ferrous Hb) Prostaglandin Prostaglandin H synthase-2 Prostacyclin Peroxynitrite parts per million Permeability transition pore Relative light unit Reactive nitrogen species Reactive oxygen species Standard deviation Soluble guanylate cyclase 3-Morpholino-sydnonimine Smooth muscle cells N -(Acetyloxy)-3-nitrosothiovaline Sodium nitroprusside Superoxide dismutase Cu,Zn-SOD, cytosolic Mn-SOD, mitochondrial EC-SOD, extracellular Cu,Zn-SOD Tricarboxylic acid Thin-layer chromatography Thioredoxin Thromboxane Vascular endothelial growth factor Vascular smooth muscle cells without Xanthine oxidase 1-Benzyl-3-(5-hydroxymethyl-2-furyl)indazole iii Publications Results from this work were published in the following articles:


Albumin replacement and septic shock NEJM 2014 47%

(Continued.) Characteristic Albumin Group (N = 903) Crystalloid Group (N = 907) 105±22 74±16 10.0±4.9 106±20 73±15 9.8±4.7 50 20–100 50 25–100 2.3 1.4–4.2 24.1±6.3 10.9±2.1 2.5 1.6–4.3 24.2±6.2 11.0±2.0 73 65–79 73 68–80 8 6–10 8 5–10 188 (20.8) 361 (40.0) 236 (26.1) 89 (9.9) 29 (3.2) 565 (62.6) 709 (78.5) 208 (22.9) 303 (33.4) 248 (27.3) 115 (12.7) 33 (3.6) 570 (62.8) 737 (81.3) 153 (16.9) 452 (50.1) 176 (19.4) 479 (52.8) Physiological variable¶ Heart rate — beats/min Mean arterial pressure — mm Hg Central venous pressure — mm Hg Urine output — ml/hr Median Interquartile range Lactate — mmol/liter Median Interquartile range Serum albumin — g/liter Hemoglobin — g/dl Central venous oxygen saturation — % Median Interquartile range SOFA score‖ Median Interquartile range Organ dysfunction — no.