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The MEDLINE database was searched from 1966 to April 2013 to ﬁnd randomized trials evaluating a restrictive hemoglobin transfusion trigger of <7 g/dL, compared with a more liberal trigger.
A Meta-analysis of Randomized Controlled Trials Allan J.
Severe skeletal-muscle wasting and weakness occurring during critical illness are associated with a prolonged need for mechanical ventilation and rehabilitation.2 In many studies, the degree of energy deficit accumulating in critically ill patients is strongly associated with the duration of stay in the ICU, which, in turn, is associated with an increased incidence of infectious complications and risk of death.1 Until recently, however, the causality of these associations remained unclear, since the majority of studies that formed the basis of published recommendations for feeding ICU patients were either observational or small interventional studies.3,4 Recently, the field of critical care nutrition has been revived by the findings of several randomized, controlled trials, which have opened a new debate on nutritional practice in the ICU.
A Randomized Clinical Trial Recent studies have suggested the potential effectiveness of targeting the vascular component of melasma.1-4 The copper bromide laser (Dual Yellow;
results of an openlabel non-randomized clinical trial Philippe Gautreta,b$, Jean-Christophe Lagiera,c$, Philippe Parolaa,b, Van Thuan Hoanga,b,d, Line Meddeba, Morgane Mailhea, Barbara Doudiera, Johan Courjone,f,g, Valérie Giordanengoh, Vera Esteves Vieiraa, Hervé Tissot Duponta,c, Stéphane Honoréi,j, Philippe Colsona,c, Eric Chabrièrea,c, Bernard La Scolaa,c, Jean-Marc Rolaina,c, Philippe Brouquia,c, Didier Raoulta,c*.
Research Original Investigation | CARING FOR THE CRITICALLY ILL PATIENT Effect of a Perioperative, Cardiac Output–Guided Hemodynamic Therapy Algorithm on Outcomes Following Major Gastrointestinal Surgery A Randomized Clinical Trial and Systematic Review RupertM.Pearse,MD;
The review concludes with a discussion of randomized trials comparing restrictive versus liberal transfusion strategies and a consideration of blood conservation techniques.
Accordingly, Asfar et al.4 now report in the Journal the results of a large, randomized, controlled trial of targeting a low MAP (65 to 70 mm Hg) versus a high MAP (80 to 85 mm Hg) among patients with septic shock at 29 centers in France.
 reviewed studies that focused on mandated preoperative weight loss from 2011–2016 indicated that there was no data from any randomized controlled trial, large prospective study, or meta-analysis to support the practice of insurance-mandated preoperative weight loss.
10.1136/bmj.f6104 (Published 29 October 2013) Page 1 of 9 Research RESEARCH Non-publication of large randomized clinical trials:
In this trial, patients randomized to receive a lower tidal volume (Vt) [4-6 mL/kg predict body weight (PBW), and maintenance of plateau pressure between 25 and 30 cmH2O] had a survival benefit.
a prospective randomized controlled trial Joerg C Schefold1*, Stephan von Haehling2, Rene Pschowski1,3, Thorsten Onno Bender1, Cathrin Berkmann1, Sophie Briegel1, Dietrich Hasper1 and Achim Jörres1 Abstract Introduction:
a randomized controlled trial Jean-Christophe Richard1,2,3*, Frédérique Bayle1, Gael Bourdin1, Véronique Leray1, Sophie Debord1, Bertrand Delannoy1, Alina Cividjian Stoian1,2, Florent Wallet1, Hodane Yonis1,2 and Claude Guerin1,2,3 Abstract Introduction:
Twenty-eight observational studies (no randomized control trials) were included.
ORIGINAL ARTICLE Bright Light Treatment in Elderly Patients With Nonseasonal Major Depressive Disorder A Randomized Placebo-Controlled Trial Ritsaert Lieverse, MD;
New scientific evidence on Irritable Bowel Syndrome The OBIS Study Introduction • The OBIS study evaluated the therapeutic efficacy of Otilonium Bromide (OB) on symptom control, during and following treatment in patients with Irritable Bowel Syndrome (IBS) in a double blind, randomized, superiority trial vs placebo1.
a systematic review and meta-analysis of randomized controlled trials Waleed Alhazzani1*, Mohamed Alshahrani2, Roman Jaeschke1,3, Jean Marie Forel4, Laurent Papazian4, Jonathan Sevransky5 and Maureen O Meade1,3 Abstract Introduction:
a meta-analysis of randomized controlled trials Critical Care 2014, 18:R109 doi:10.1186/cc13896 Shu Ling Hu (firstname.lastname@example.org) Hong Li He (email@example.com) Chun Pan (firstname.lastname@example.org) Ai Ran Liu (email@example.com) Song Qiao Liu (firstname.lastname@example.org) Ling Liu (email@example.com) Ying Zi Huang (firstname.lastname@example.org) Feng Mei Guo (email@example.com) Yi Yang (firstname.lastname@example.org) Hai Bo Qiu (email@example.com) ISSN Article type 1364-8535 Research Submission date 26 September 2013 Acceptance date 13 May 2014 Publication date 28 May 2014 Article URL http://ccforum.com/content/18/3/R109 This peer-reviewed article can be downloaded, printed and distributed freely for any purposes (see copyright notice below).
In consideration of the limited number of randomized controlled trials related to such a question, it was not possible to draw any definite conclusion from the review.
Through randomized trials, short-term use of neuromuscular blockade at initial stage of mechanical ventilation, prone ventilation in severe ARDS, and extracorporeal membrane oxygenation in ARDS with influenza pneumonia showed beneficial efficacy.