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 iv.  We recommend that sedative medications be titrated to maintain a light rather than a deep level of sedation in adult ICU patients, unless clinically contraindicated ( 1B).

Phytocannabinoids Structure* Concentration† (% dry weight) Boiling Point °C§ Properties Δ-9-tetrahydrocannabinol (THC) 0.1-25% 157 Euphoriant Analgesic Antiinflammatory Antioxidant Antiemetic 0.1-2.89% 160-180 Anxiolytic Analgesic Antipsychotic Antiinflammatory Antioxidant Antispasmodic 0.0-1.6% 185 Oxidation breakdown product Sedative Antibiotic 0.0-0.65% 220 Antiinflammatory Antibiotic Antifungal 0.03-1.15% MP 52 Antiinflammatory Antibiotic Antifungal CH3 OH CH3 H3C O cannabidiol (CBD) CH3 OH CH2 OH CH3 cannabinol (CBN) CH3 OH CH3 CH3 O cannabichromene (CBC) OH O cannabigerol (CBG) OH HO 112 CANNABIS THERAPEUTICS IN HIV/AIDS FIGURE 1 (continued) Structure* Concentration† (% dry weight) Boiling Point °C§ Properties Δ-8-tetrahydrocannabinol (Δ-8-THC) 0.0-0.1% 175-178 Resembles Δ-9-THC Less psychoactive More stable Antiemetic 0.0-1.36% <

Control of agitation should be achieved using parenteral rapid-acting sedative-hypnotic agents that are cross-tolerant with alcohol.

➢ Anxiolytique ➢ Sedative ➢ Hypnotique ➢ Amnesiante (amnesie anterograde) ➢ Anti-convulsivante ➢ Myorelaxante (peut expliquer l'ataxie) ➢ Sujette à tolerance et à dependance (psychique puis physique) 3/9 2017-2018 VI) Les benzodiazepines Pharmacocinetique Ce sont toutes des molécules lipophiles.

GuidelinesAnxiety International Journal of Psychiatry in Clinical Practice, 2012;

Syncro Syncro.css : Team's presentation 1.

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