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10.1136/bmj.f6104 (Published 29 October 2013) Page 1 of 9 Research RESEARCH Non-publication of large randomized clinical trials:
There is accumulating evidence that restricting blood transfusions improves outcomes, with newer trials showing greater beneﬁt from more restrictive strategies.
PubMed, Embase, Cochrane Central Register of Controlled Trials (January 1, 2005, through May 8, 2017), ClinicalTrials.gov, and the US Food and Drug Administration Adverse Event Reporting System.
The MIMO model verified that specific CA3-to-CA1 firing patterns were critical for the successful encoding of sample phase information on more difficult DMS trials.
a systematic review and meta-analysis of randomized controlled trials Waleed Alhazzani1*, Mohamed Alshahrani2, Roman Jaeschke1,3, Jean Marie Forel4, Laurent Papazian4, Jonathan Sevransky5 and Maureen O Meade1,3 Abstract Introduction:
Perkins at Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom, or at email@example.com.
Møller, M.D., Per Winkel, M.D., D.M.Sci., and Jørn Wetterslev, M.D., Ph.D., for the 6S Trial Group and the Scandinavian Critical Care Trials Group* A BS T R AC T Background Hydroxyethyl starch (HES) 130/0.4 is widely used for fluid resuscitation in intensive care units (ICUs), but its safety and efficacy have not been established in patients with severe sepsis.
Severe skeletal-muscle wasting and weakness occurring during critical illness are associated with a prolonged need for mechanical ventilation and rehabilitation.2 In many studies, the degree of energy deficit accumulating in critically ill patients is strongly associated with the duration of stay in the ICU, which, in turn, is associated with an increased incidence of infectious complications and risk of death.1 Until recently, however, the causality of these associations remained unclear, since the majority of studies that formed the basis of published recommendations for feeding ICU patients were either observational or small interventional studies.3,4 Recently, the field of critical care nutrition has been revived by the findings of several randomized, controlled trials, which have opened a new debate on nutritional practice in the ICU.
Using an open source electronic data-capturing system for clinical trials in low-income countries Roselyne Vallo1, Halbou A.
Reprint from The Review of DIABETIC STUDIES Vol 8 No 3 2011 Special Issue on Drug Development and Clinical Trials in Type 2 Diabetes The Review of DIABETIC REVIEW STUDIES Metabolic Memory and Individual Treatment Aims in Type 2 Diabetes – Outcome-Lessons Learned from Large Clinical Trials Cristina Bianchi and Stefano Del Prato Department of Endocrinology and Metabolism, Section of Diabetes and Metabolic Diseases, University of Pisa, Italy.