RASOANAIVO Drug bio discovery, invention and business

Science in the Least Developed Countries:
Examples of successful experiences

Drug bio-discovery, invention and business

Philippe Rasoanaivo
Institut Malgache de Recherches Appliquées

Economic Sciences

Business
Invention
Biodiversity and drug discovery

Biodiversity Paradox

Wealth

Poverty

Biodiversity Convention

Conservation

IPR related to
traditional knowledge

Equitable benefit sharing

Natural product Drug discovery
Costly
Biopiracy

Time-consuming

Economic drugs
Orphan drugs

Marketable Drug

Drugs for malaria
Erythrocytic Stage
Antimalarial
drugs

Hepatic stage

Finding funded project ??
PAL+ funded project

Follow-up programme
H3CO

10

HO

Publications

OH

Patent
NH

HO

OCH3

Funded project

OH

Tazopsine
■ M. Carraz, A. Jossang, JF Franetich, A. Siau, L. Ciceron, F. Frappier,
P. Rasoanaivo, G. Snounou, D. Mazier, PLoS Medicine 2006 (in press).
■ M. Dominique, M. Carraz, JF Franetich, A. Jossang, R. Joyeau,
P. Rasoanaivo, F. Frappier, PCT/EP 2005/005239.
■ French funding agency: Agence Nationale de la Recherche (2006)

Additional work

Funded project:

Cultivation
Local communities

Chronic degenerative diseases
Advanced Glycation End-products
Misfolding proteins

Integrated
approach

►Diabetes

Cardiovascular and
Erectile disorders

► Memory impairment

Strategy
Contract with local communities
Patents
Scientific work (secrecy)
2 patent priority applications

Business-driven activities
Selling
phytomedicine
Supporting
the cost of patents
Approaching
Pharmaceutical companies
■ Up-front payment of collection of genetic resources
■ Royalties on products developed from the material

Economic
impact